OBJECTIVE Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury. Systemic C5 inhibition in clinical studies has resulted in mixed results and the role of earlier complement components (e.g., C3a), upstream from C5 cleavage, has not been elucidated for ...

We want you to consider in detail the paper published in the January 2013 issue of Journal of Clinical Biochemistry and Nutrition, by Tomoki Aomatsu et al. entitled “Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice”. The authors have evaluated the pathophysiological role of the complement system in a mice colitis model. To stu...

This paper reports on the effect of ageing by free-burning arcs in 7.5% C5-fluoroketone (C5-FK) with 92.5% technical air comparison to that (80% N2, 20% O2) at 1.3bar absolute pressure. The gases are aged applying a series dissipating an accumulated energy around 315kJ. It is found arc voltages and C5-FK same range do not vary significantly as function or current amplitude (∼40-900 A). Contact ...

In this paper, the attenuation coefficients of X-rays for a range voltages (20-35) kV were studied copper-based alloys (Cu + 0.05 AL 0.03 Ti) according to order (A1,A2,A3,A4,A5),by adding percentages silver (X=1,2,3,4,5)% with two particle sizes (Nano) and (Micro) alloy ( Cu92-x +5%Al +3%Ti+ Ag x) orders (B1,B2,B3,B4,B5) (C1,C2,C3,C4,C5) All sintered at (9000C) period (4) hours.The results show...

STUDY DESIGN Retrospective study. OBJECTIVES To evaluate the efficacy of bilateral C4-5 foraminotomy in preventing occurrence of postoperative C5 palsy and to identify possible risk factors for its development. METHODS A total of 70 consecutive patients who underwent open-door laminoplasty with bilateral C4-5 foraminotomy were included. Clinical, radiographic, and operative data was reviewe...

BACKGROUND & AIMS Complement activation plays an important role in the local pathogenesis of ischemia/reperfusion (I/R) injury. We investigated the action of anti-C5 monoclonal antibody (mAb) on local and remote organ injuries after intestinal I/R in the rat. METHODS Under anesthesia, functional anti-rat C5 mAb (18A), an isotype-matched control anti-C5 mAb (16C), or vehicle (phosphate-buffere...

The relative inflammatory roles of neutrophils, selectins, and terminal complement components are investigated in this study of skeletal muscle reperfusion injury. Mice underwent 2 h of hindlimb ischemia followed by 3 h of reperfusion. The role of neutrophils was defined by immunodepletion, which reduced injury by 38%, as did anti-selectin therapy with recombinant soluble P-selectin glycoprotei...

The adult respiratory distress syndrome is characterized by arterial hypoxemia as a result of increased alveolar capillary permeability to serum proteins in the setting of normal capillary hydrostatic pressures. Because bacterial sepsis is prominent among the various diverse conditions associated with altered alveolar capillary permeability, we studied the effect of bacteremia with attendant co...