نتایج جستجو برای: اهمیت نسبی siv

تعداد نتایج: 117381  

2009
Afam Okoye Haesun Park Mukta Rohankhedkar Lia Coyne-Johnson Richard Lum Joshua M. Walker Shannon L. Planer Alfred W. Legasse Andrew W. Sylwester Michael Piatak Jeffrey D. Lifson Donald L. Sodora Francois Villinger Michael K. Axthelm Joern E. Schmitz Louis J. Picker

Depletion of CD8(+) lymphocytes during acute simian immunodeficiency virus (SIV) infection of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication and rapid disease progression, consistent with a major role for CD8(+) lymphocytes in determining postacute-phase viral replication set points. However, we report that CD8(+) lymphocyte depletion is also associat...

Journal: :PLoS Computational Biology 2009
Joel O. Wertheim Michael Worobey

Great strides have been made in understanding the evolutionary history of simian immunodeficiency virus (SIV) and the zoonoses that gave rise to HIV-1 and HIV-2. What remains unknown is how long these SIVs had been circulating in non-human primates before the transmissions to humans. Here, we use relaxed molecular clock dating techniques to estimate the time of most recent common ancestor for t...

2012
Jeanette Reece Janka Petravic Mehala Balamurali Liyen Loh Shayarana Gooneratne Rob De Rose Stephen J. Kent Miles P. Davenport

Persistence of HIV DNA presents a major barrier to the complete control of HIV infection under current therapies. Most studies suggest that cells with latently integrated HIV decay very slowly under therapy. However, it is much more difficult to study the turnover and persistence of HIV DNA during active infection. We have developed an "escape clock" approach for measuring the turnover of HIV D...

Journal: :Journal of virology 1996
C Yang R W Compans

It was previously reported that truncation or proteolytic removal of the C-terminal 16 amino acids (the R peptide) from the cytoplasmic tail of the murine leukemia virus (MuLV) envelope protein greatly increases its fusion activity. In this study, to investigate the specificity of the effect of the R peptide on the fusion activity of viral envelope proteins, we expressed simian immunodeficiency...

Journal: :Journal of virology 2012
Matthias Tenbusch Ralf Ignatius Vladimir Temchura Ghulam Nabi Bettina Tippler Guillaume Stewart-Jones Andres M Salazar Ülrike Sauermann Christiane Stahl-Hennig Klaus Uberla

To explore the efficacy of novel complementary prime-boost immunization regimens in a nonhuman primate model for HIV infection, rhesus monkeys primed by different DNA vaccines were boosted with virus-like particles (VLP) and then challenged by repeated low-dose rectal exposure to simian immunodeficiency virus (SIV). Characteristic of the cellular immune response after the VLP booster immunizati...

Journal: :Blood 2011
Nichole R Klatt Carol L Vinton Rebecca M Lynch Lauren A Canary Jason Ho Patricia A Darrah Jacob D Estes Robert A Seder Susan L Moir Jason M Brenchley

HIV infection is characterized by immune system dysregulation, including depletion of CD4+ T cells, immune activation, and abnormal B- and T-cell responses. However, the immunologic mechanisms underlying lymphocytic dysfunctionality and whether it is restricted to immune responses against neo antigens, recall antigens, or both is unclear. Here, we immunized SIV-infected and uninfected rhesus ma...

Journal: :Blood 2012
Ivona Pandrea Elaine Cornell Cara Wilson Ruy M Ribeiro Dongzhu Ma Jan Kristoff Cuiling Xu George S Haret-Richter Anita Trichel Cristian Apetrei Alan Landay Russell Tracy

HIV infection is associated with increased risk of cardiovascular complications, the underlying mechanism of which remains unclear. Plasma levels of the coagulation biomarker D-dimer (DD) correlate with increased mortality and cardiovascular events in HIV-infected patients. We compared the incidence of cardiovascular lesions and the levels of the coagulation markers DD and thrombin antithrombin...

Journal: :Journal of virology 1993
T A Rizvi A T Panganiban

Packaging of retroviral RNA is attained through the specific recognition of a cis-acting encapsidation site (located near the 5' end of the viral RNA) by components of the Gag precursor protein. Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) are two lentiviruses that lack apparent sequence similarity in their putative encapsidation regions. We used SIV vecto...

Journal: :Journal of immunology 1998
T M Allen J Sidney M F del Guercio R L Glickman G L Lensmeyer D A Wiebe R DeMars C D Pauza R P Johnson A Sette D I Watkins

The majority of immunogenic CTL epitopes bind to MHC class I molecules with high affinity. However, peptides longer or shorter than the optimal epitope rarely bind with high affinity. Therefore, identification of optimal CTL epitopes from pathogens may ultimately be critical for inducing strong CTL responses and developing epitope-based vaccines. The SIV-infected rhesus macaque is an excellent ...

Journal: :Journal of virology 2006
Erica K Sloan Ross P Tarara John P Capitanio Steve W Cole

Clinical and in vitro studies have shown that activity of the autonomic nervous system (ANS) can stimulate lentivirus replication. To define the potential anatomical basis for this effect, we analyzed the spatial relationship between catecholaminergic neural fibers and sites of simian immunodeficiency virus (SIV) replication in lymph nodes from rhesus macaques experimentally infected with SIVma...

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