3-Phenylaminoisoxazol-5(2H)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. When the N-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. Evidence is presented that the reactions proceed by initial addition of the tertiary arnine to C-4

Available constraints on metamorphic reaction rates derived from the study of natural systems are similar to, or slightly lower than, the bulk strain rates measured in the same rocks. Here, we explore whether this apparent relationship is merely coincidence or due to a more fundamental mechanistic link between reaction and strain. Grain boundary migration accommodated dislocation creep (GBMDC) ...

Attempts to improve the diagnosis of tuberculosis (TB) in high-burden countries has resulted in significant funding and initiatives to change the method of diagnosis of TB from light microscopy supplemented with X-ray to a sophisticated diagnostic algorithm based on the latest technological innovations. Such activities are overdue and should be welcomed, but the lack of skills and support avail...

BACKGROUND Pancreatic cancer is a highly aggressive malignancy and will become the second leading cause of cancer-related death in the USA and also in Germany by 2030. Furthermore, the majority of patients with pancreatic ductal adenocarcinoma (PDAC) will present with distant metastases, limiting surgical management in this population as there is little evidence available to support surgical or...

Using religion to improve health is an age-old practice. However, using religion and enlisting religious authorities in public health campaigns, as exemplified by tobacco control interventions and other activities undertaken by WHO's Eastern Mediterranean Regional Office, is a relatively recent phenomenon. Although all possible opportunities within society should be exploited to control tobacco...

BACKGROUND In the present study we review and discuss the current evidence and suggest how to proceed in the management of oligometastatic disease in upper gastrointestinal cancer. METHODS An electronic search of the PubMed database for relevant articles was performed. RESULTS Both the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as '...

background & aim: skin-to-skin contact immediately after birth plays a pivotal role in proper breastfeeding and mother-infant interaction. despite numerous benefits of mother-infant skin-to-skin contact, this health behavior is not performed by many midwives. this study aimed to evaluate the influential factors for mother-infant skin-to-skin contact based on the precede-proceed model from the p...