Mechanical ventilation can worsen morbidity and mortality by causing ventilator-associated lung injury, especially where adverse ventilatory strategies are employed. Adverse strategies commonly involve hyperventilation, which frequently results in hypocapnia. Although hypocapnia is associated with significant lung alterations (e.g., bronchospasm, airway edema), the effects on alveolar-capillary...

Normal and nephrectomized SpragueDawley rats were treated with CoCI2 at three dose levels, 10, 20, and 25 tm/ 100 g body weight. The effects of this drug on acid-base balance were related to the production of erythropoietin. Within 6 hr after the administration of CoCI2 to normal rats, a dose-related respiratory alkalosis occurred associated with an increase in the affinity of hemoglobin for ox...

The protocol of the experiment was designed as follows. In the morning, the instrument was prepared for operation by calibration and verification with whole blood gas control samples (Quantra; Dade Division of American Hospital Supply Corp., Miami, FL 33152). An IL blood gas control, ContrIL, was analyzed for P02 before and after the determination on blood from the patient in surgery. Two level...

The aims of this study were to determine 1) whether ventilatory adaptation occurred over a 5-day exposure to a constant elevation in end-tidal PCO2 and 2) whether such an exposure altered the sensitivity of the chemoreflexes to acute hypoxia and hypercapnia. Ten healthy human subjects were studied over a period of 13 days. Their ventilation, chemoreflex sensitivities, and acid-base status were ...

Price, Rs. 5-10. ^ t^e acj(i.base During recent years, the disturbance more -widely equilibrium in the body is being m causation of recognized as an important factor ?00(J deal of disease. Within the last 50 y?a? 5 g helped to throw research work has been done which ^ chemical light on this difficult physiolog eraiiy accepted problem. It has, for instance, Pe ? fj [n a state comthat for the org...

scar tissue, although it must benoted that part of the fibrosis may be due to the X-rays. One case of group 2 is well worth noting from the literature. Simons8 reports a case of a youth, aged eighteen years, in whom a paraplegia developed suddenly, and laminectomy was performed. A large granulomatous mass was found. It was inoperable. X-radiation was given. The patient died three months later f...