Die RNA ist ein Molekül, das sowohl genetische Informationen speichern als auch katalytische Reaktionen ausführen kann. Dieser beobachtete Dualismus rückt die ins Rampenlicht der Konzepte über den Ursprung des Lebens. RNA-Welt-Hypothese geht davon aus, dass Leben aus selbst replizierenden RNA-Molekülen entstand, sich zu immer komplexeren Strukturen entwickelten. Vor kurzem haben wir gezeigt, mi...

Noncoding ribonucleic acids micro-RNA is involved in the regulation of gene expression have major roles in the post-transcriptional level. A micro-RNA alone several causes down regulation of mRNA transcript of the target. Thus, small changes in the expression of a micro RNA may lead to significant changes in gene expression are different. Micro- RNA as key regulators of immune cell lineage diff...

Background: The stress is one of main factors effects on production system. Several factors (both genetic and environmental elements) regulate immune response to stress. Objectives: In order to determine the major immune system regulatory genes underlying stress responses, a learning Bayesian network approach for those regulatory genes was applied to RNA-...

lots of viruses, in particular rna viruses, have high mutation rates and relatively short generation times. particle stability during infection in nature or in laboratory triggers the evolutionary event toward different mechanisms such as genome segmentation, point mutation and  recombination. the frequency of mutant genomes increase and modify  the previous distribution, which, consequently, l...

Abstract The development of approaches for predictive calculation hybridization properties various nucleic acid (NA) derivatives is the basis rational design NA-based constructs. Modern advances in computer modeling methods provide feasibility these calculations. We have analyzed possibility calculating energy DNA/RNA and RNA/RNA duplex formation using representative sets complexes (65 75 compl...

Background and Aims: Hepatitis C virus is one of the viral infections transmitted by blood transfusion. Patients with thalassaemia frequently need blood transfusion and are in danger of HCV infection. In most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. Liver is the main site of HCV replication ...