نتایج جستجو برای: γ h2ax
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Folate is an essential water-soluble vitamin in food and nutrition supplements. As a one-carbon source, it is involved in many central regulatory processes, such as DNA, RNA, and protein methylation as well as DNA synthesis and repair. Deficiency in folate is considered to be associated with an increased incidence of several malignancies, including cervical cancer that is etiologically linked t...
Ionizing radiation-induced foci (IRIF) of DNA repair-related proteins accumulated at DNA double-strand break (DSB) sites have been suggested to be a powerful biodosimetric tool. However, the relationship between IRIF induction and biologically relevant endpoints, such as cell death and formation of chromosome rearrangements is less clear, especial...
Exposure of mammalian cell nuclei with charged particles leads to the spatially defined production of damaged chromatin domains along the particle trajectories. Analysis of track morphology facilitates studies on the dynamics of radiation-induced protein foci associated with lesion processing. Recently we described the discrete formation of γ-H2AX foci and the recruitment of repair related prot...
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