The stability constants of complexes formed by Thallium (I) with Serine and Leucine have been investigated in aqueous medium, the complex with metal Serine as 1:1, 1:2 and complexes of the Tl(I) with Leucine as 1:1, 1:2 have been reported. The values of formation constant of Serine are log β1 = 2.1760, log β2 = 3.85325 at 308K and log β1 = 1.9030, log β2 = 3.6739 at 318K and complexes of Tl(I) ...

Antiphospholipid Abs (APLAs) are associated with thrombosis and recurrent fetal loss. These Abs are primarily directed against phospholipid-binding proteins, particularly β(2)GPI, and activate endothelial cells (ECs) in a β(2)GPI-dependent manner after binding of β(2)GPI to EC annexin A2. Because annexin A2 is not a transmembrane protein, the mechanisms of APLA/anti-β(2)GPI Ab-mediated EC activ...

Diabetes mellitus (DM) is the fifth deadliest disease in the United States with an annual economic cost estimated over $100 billion. Cardiovascular disease (CVD) represents the most life threatening consequence of DM accounting for the death of up to 65% of DM patients. Aggressive efforts aimed at treating and controlling the classic CVD risk factors over the last few decades have brought along...

Antiphospholipid syndrome (APS) is characterized by thrombosis and the presence of antiphospholipid antibodies (aPL) that directly recognizes plasma β(2)-glycoprotein I (β(2) GPI). Tissue factor (TF), the major initiator of the extrinsic coagulation system, is induced on monocytes by aPL in vitro, explaining in part the pathophysiology in APS. We previously reported that the mitogen-activated p...