We describe a case of a young male without stroke risk factors who presented with a sudden onset of left-sided weakness, left hand numbness, and left eye blurriness. CT scan of the head without contrast and diffusion-weighted MRI of the brain with contrast revealed an ischemic stroke in the right middle cerebral artery distribution. Transesophageal echocardiography (TEE) revealed a mobile pedun...

BACKGROUND Thalassemic patients demonstrate an increased rate of extracardiac vascular complications and increased carotid wall intima-media thickness (cIMT), but very low prevalence of coronary artery disease (CAD). We investigated the atheroma burden by assessing the coronary artery calcium (CAC) and cIMT in these patients. METHODS We examined 37 patients with β-thalassemia and 150 healthy ...

The therapeutic use of patient-specific induced pluripotent stem cells (iPSCs) is emerging as a potential treatment of β-thalassemia. Ideally, patient-specific iPSCs would be genetically corrected by various approaches to treat β-thalassemia including lentiviral gene transfer, lentivirus-delivered shRNA, and gene editing. These corrected iPSCs would be subsequently differentiated into hematopoi...

BACKGROUND AND AIM Both thalassemia and carnitine deficiency represent independent causes of erythropoietin resistance, and thus anemia, in uremic patients. We evaluated the unknown long-term effects of L-carnitine administration in β-thalassemic on chronic hemodialysis. METHODS We studied twelve subjects (M = 8; F = 4) affected by β-thalassemia minor (β-thal; HbA2 level = 6.6 ± 0.6%) and for...

Extramedullary hematopoiesis (EMH), as a compensatory phenomenon, refers to the blood cell formation outside of bone marrow that occurs once cells in circulatory system fail meet individuals’ needs. EMH is rare moderate severe beta thalassemia because most symptomatic patients are effectively managed with transfusion. However, receive transfusions like β-thalassemia intermedia (β-TI) indicated ...

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Few literatures have elaborated on the clinical characteristics of children with thalassemia from low-prevalence areas. A retrospective analysis was conducted on children genetically confirmed with thalassemia at Seoul National University Children's Hospital in Korea. Nine children (1α thalassemia trait, 6β thalassemia minor, 2β thalassemia intermedia) were diagnosed with thalassemia at median ...

Đặt vấn đề: Thalassemia và bệnh huyết sắc tố là nằm trong nhóm các rối loạn di truyền của dòng hồng cầu phổ biến trên thế giới. Việc phát hiện người mang gen thalassemia thể nhẹ hay bất thường ở trưởng thành có thay đổi chỉ số cầu, góp phần làm giảm gánh nặng do gây ra. Mục tiêu: Xác định tỷ lệ lý tố, gene thalasemia biểu về máu ngoại vi. Phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả, 200 ...

To investigate the molecular basis of β -thalassemia intermedia in Northern Iraq and evaluate its management practices, a total of 74 patients from 51 families were enrolled. The patients were clinically and hematologically reevaluated, and had their β-thalassemia mutations characterized, as well as the number of α-globin genes and Xmn I (G)γ-158 (C>T) polymorphism studied. Out of 14 β-thalasse...