Objective: To investigate the effect of butylphthalide combined with fasudil in treatment subarachnoid hemorrhage (SAH) cerebral vasospasm (CVS) on inflammatory factors, cognitive function and vascular endothelial function.
 Methods: It is a retrospective study which total 104 patients SAH CVS admitted to Baoding First Central Hospital from July 2020 February 2022 were selected randomly di...

During chemical hypoxia induced by cobalt chloride (CoCl2), hypoxia-inducible factor 1alpha (HIF1-alpha) mediates the induction of a variety of genes including erythropoietin and vascular endothelial growth factor. We used glioma cells with oxidative phosphorylation-dependent (D54-MG) and glycolytic-dependent (U251-MG) phenotypes to monitor HIF1-alpha regulation in association with redox respon...

PURPOSE To investigate the cytokine concentrations in the aqueous humor of patients with refractory polypoidal choroidal vasculopathy (PCV). METHODS Three separate groups of patients were studied-refractory PCV (Group A, 41 eyes), stable PCV (Group B, 39 eyes) and senile cataract (Group C, 44 eyes). Aqueous humor samples were collected at two time points for Groups A and B-before the first in...

During chemical hypoxia induced by cobalt chloride (CoCl2), hypoxia-inducible factor 1A (HIF1-A) mediates the induction of a variety of genes including erythropoietin and vascular endothelial growth factor. We used glioma cells with oxidative phosphorylation–dependent (D54-MG) and glycolytic-dependent (U251-MG) phenotypes to monitor HIF1-A regulation in association with redox responsiveness to ...

The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the lev...

An adequate vascular supply is important to provide endocrine and paracrine signals during follicular development. We evaluated the direct in vivo effects of both the GnRH-agonist Leuprolide acetate (LA) and the GnRH-antagonist Antide (Ant) on the expression of VEGF-A and ANPT-1 and their receptors in ovarian follicles from prepubertal eCG-treated rats. We also examined whether the changes obse...

introduction: pulsed dye laser (pdl) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. the aim of this study was to evaluate alterations of serum vascular endothelial growth factor (vegf) level in infantile hemangioma (ih) patients after laser treatment and effects of pdl irradiation on human umbilical vein endothelial cells (huvec...

Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic trioxide on the release of tumor necrosis factor-α (TNF-α) and vascular endoth...