Quorum sensing controls the luminescence of Vibrio fischeri through the transcriptional activator LuxR and the specific autoinducer signal produced by luxI. Amino acid sequences of these two genes were analyzed using bioinformatics tools. LuxI consists of 193 amino acids and appears to contain five α-helices and six ß-sheets when analyzed by SSpro8. LuxI belongs to the autoinducer synthetase fa...

A pincer-like chiral auxiliary strategy for synthesizing various optically active α,α-disubstituted amino acids in high yields with excellent enantioselectivities is described.

Thin-layer chromatography of α-amino acids has been performed on layers prepared from a 1:4 stannic arsenate–cellulose mixture. RF values of the amino acids were determined after development with a variety of mobile phases. Important synthetic ternary separations have been achieved on the basis of different RF values. Lysine and threonine have been selectively separated and quantitatively deter...

The stereoselective synthesis of β -amino acids and their derivatives has been an active area of research, due to the importance of β -amino acids in various fields [1]. In particular, non-proteinogenic β -amino α-hydroxy acids are found in many natural products and drugs, for example N-benzoyl-3-phenylisoserine as a side-chain of taxol which has been approved for treatment of ovarian and breas...

The effects of two dietary proteins on α-amino acids, calcium and phosphorus concentrations in plasma, stomach and intestine were investigated in rats trained to consume, in a single two-hour daily meal, diets containing α-lactalbumin (α-la) or whey protein concentrate (WPC) for two weeks. The results indicated that the concentrations of calcium and phosphorus in the gastrointestinal tract and ...

BACKGROUND Nitric oxide sensitive guanylyl cyclase (NOsGC) is a heterodimeric enzyme formed by an α- and a β₁-subunit. A splice variant (C-α₁) of the α₁-subunit, lacking at least the first 236 amino acids has been described by Sharina et al. 2008 and has been shown to be expressed in differentiating human embryonic cells. Wagner et al. 2005 have shown that the amino acids 61-128 of the α₁-subun...

A simple and efficient method for the synthesis of N,N'-orthogonally protected imide tethered peptidomimetics is presented. The imide peptidomimetics were synthesized by coupling the in situ generated selenocarboxylate of N(α)-protected amino acids with N(α)-protected amino acid azides in good yields. The protocol was also successfully applied for the synthesis of hybrid tripeptidomimetics bear...