Factor XIII deficiency (FXIIID) is an extremely rare hemorrhagic disorder with a prevalence of 1/3-5 million. Management of disease is performed by fresh frozen plasma (FFP), Cryoprecipitate (CP) or FXIII concentrate (Fibrogammin P®). Our objective was to assess safety and effectiveness of Fibrogammin P® in patients with FXIIID. For this purpose we designed this long-term follow up study on a l...

BACKGROUND Visualization of the precise course of the visual pathways is relevant to prevent damage that may inflict visual field deficits during neurosurgical resections. In particular the optic radiations (OR) are susceptible to such damage during neurosurgery. Cortical pathways can be mapped in vivo, by using Diffusion Tensor Imaging (DTI). Visualization of these pathways would be potentiall...

a brief background to the development of the rock engineering design process is given, showing that since the development of the science of mathematics, deterministic methods have been used to perform various calculations. the variability of rock properties and support characteristics have always been known. however, they were not explicitly used in design but compensated for by the use of a sa...

The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in adult neurogenesis appear to be a common hallmark of different neurodegenerative diseases, understanding the molecular mechanisms controlling ...

The design of a steep reinforced slope with an adequate Factor Of Safety (FOS) is classical geotechnical problem. While designing soil slope, it necessary to accurately determine the tensile force be resisted by reinforcement achieve target FOS value and length geotextile provided at top bottom embankment perform all required safety checks. This paper presents MS Excel spreadsheet using Visual ...

The striatum has a central role in many neurobiological processes, yet little is known about the molecular control of its development. Inroads to this subject have been made, due to the discovery of transcription factors, such as the Dlx genes, whose expression patterns suggest that they have a role in striatal development. We report that mice lacking both Dlx-1 and Dlx-2 have a time-dependent ...

The Northern Sea Route is a key factor in the development of Arctic zone Russian Federation. At same time, main strategic planning documents Federation define not only goals sustainable socio-economic development, but also tasks preserving unique ecosystems. article considers way further NSR depends on coordination interests with subsoil users and shows how infrastructure leads to multiplicativ...