Lycopene is a potentially useful compound for preventing and treating cardiovascular diseases and cancers. Studies on the effects of lycopene on oxidative stress offer insights into its mechanism of action and provide evidence-based rationale for its supplementation. In this analysis, randomized controlled trials of the effects of oral lycopene supplementation on any valid outcomes of oxidative...

OBJECTIVE Lycopene is a phytochemical, found in tomatoes having singlet oxygen quenching ability higher than other antioxidants, participates in most of chemical reactions to protect critical cellular biomolecules. Present study is to analyze effect of tomato's lycopene, synthetic lycopene, its placebo form in patients of OS. METHODS Study includes 45 patients having oxidative stress, age 40-...

background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...

Prostate cancer (PCa) is a common illness for aging males. Lycopene has been identified as an antioxidant agent with potential anticancer properties. Studies investigating the relation between lycopene and PCa risk have produced inconsistent results. This study aims to determine dietary lycopene consumption/circulating concentration and any potential dose–response associations with the risk of ...

Introduction Lycopene (C40H56), as a unsaturated red-pigmented linear carotenoid, has a molecular weight of 536.85 Da, and 11 conjugated and 2 non-conjugated double bonds; it is lipophilic and therefore more soluble in organic solvents (1-3). Lycopene is a lipid-soluble antioxidant and has been inversely associated with lipid peroxidation, comprising low-density lipoprotein oxidation and reduce...

BACKGROUND Microbial production of lycopene, a commercially and medically important compound, has received increasing concern in recent years. Saccharomyces cerevisiae is regarded as a safer host for lycopene production than Escherichia coli. However, to date, the lycopene yield (mg/g DCW) in S. cerevisiae was lower than that in E. coli and did not facilitate downstream extraction process, whic...

An evaluation of the Health Professionals Follow-Up Study has detected a lower prostate cancer risk associated with the greater consumption of tomatoes and related food products. Tomatoes are the primary dietary source of lycopene, a non-provitamin A carotenoid with potent antioxidant activity. Our goal was to define the concentrations of lycopene, other carotenoids, and retinol in paired benig...

The aim of the present study was to evaluate the effects of lutein and lycopene supplementation on carotid artery intima-media thickness (CAIMT) in subjects with subclinical atherosclerosis. A total of 144 subjects aged 45-68 years were recruited from local communities. All the subjects were randomly assigned to receive 20 mg lutein/d (n 48), 20 mg lutein/d+20 mg lycopene/d (n 48) or placebo (n...

Renal cell carcinoma (RCC) is the most frequent upper urinary tract cancer in humans and accounts for 80-85% of malignant renal tumors. Eker rat represents a unique animal model to study RCC since these rats develop spontaneous renal tumors and leiomyoma, which may be due to tuberous sclerosis 2 (TSC2) mutation resulting in the activation of the mammalian target of rapamycin (mTOR) pathway. Thi...

Purpose: Chronic bacterial prostatitis (CBP) is the most common urological disease in adult males, with antibiotic therapy being the gold standard for its treatment. However, long-term therapy results in many side effects as well as bacterial resistance. For these reasons, there is a need for a new treatment modality to replace traditional antibiotic therapy. Lycopene, an extract of tomatoes, h...