نتایج جستجو برای: ymdd mutant

تعداد نتایج: 129717  

Ahmad Sarrafi Asa Ebrahimi

The objectives of the present research were to evaluate the variability induced by gamma-irradiation among a population of M8 sunflower mutant lines and to identify molecular markers associated with different seed germination traits. Experiments were carried out under well watered and water-stressed conditions using a randomized blocks design, with three replications. The studied traits consist...

Background and Aims: Q59L mutant of L-asparaginase enzyme from Escherichia coli (E. coli) has been introduced with lower side effects. This version of the enzyme might have potential applications in the treatment of leukemia patients. We utilized SHuffle T7 strain of E. coli, to produce the mutant enzyme in the presence of chaperone molecules. Materials and Methods: Q59LAsp gene was cloned in...

Journal: :iranian journal of public health 0
aa eskandarian h keshavarz f mahboudi

using mutation specific pcr assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 plasmodium falciparum isolates of malarial patients from southern areas of iran, showed 4 different situations: iwild type (108-ser) ii-mutant type (108-thr) iii-mutant type (108-asn) and iv-mixed wild and mutant type (108-ser+thr) with frequency of 58(82.8%), 2(2...

HS Shin

Low threshold Ca2+ currents mediated by T-type channels underlie burst spike activities of relay neurons in the thalamus. We have previously reported that knock-out mice for T-type channels show an enhanced nociceptive response to visceral pain, accompanied by an increase in tonic spikes in the absence of burst spikes in thalamic relay neurons. These results raised a possibility that T-type cha...

Journal: :iranian journal of basic medical sciences 0
naghmeh ahmadiankia shahroud university of medical sciences, shahroud, iran vajiheh neshati stem cell and regenerative medicine research department, iranian academic center for education, culture and research (acecr), mashhad branch, mashhad, iran zeinab neshati department of cardiology, leiden university medical center, leiden, the netherlands jim swildens department of cardiology, leiden university medical center, leiden, the netherlands antoine af de vries department of cardiology, leiden university medical center, leiden, the netherlands

objective(s): adeno-associated virus type 2 (aav2) vectors are widely used for both experimental and clinical gene therapy. a recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. in this study, a fast and simple method is presented to generate aav2 vector helper plasmids encodin...

Journal: :jundishapur journal of microbiology 0
bin zhao mycotoxin and molecular plant pathology laboratory, agricultural university of hebei, baoding, china he long si mycotoxin and molecular plant pathology laboratory, agricultural university of hebei, baoding, china zhi ying sun mycotoxin and molecular plant pathology laboratory, agricultural university of hebei, baoding, china zheng xu mycotoxin and molecular plant pathology laboratory, agricultural university of hebei, baoding, china zhan chen institute of pomology, hebei academy of agricultural and forestry sciences, shijiazhuang, china jin lin zhang mycotoxin and molecular plant pathology laboratory, agricultural university of hebei, baoding, china

conclusions expression levels of 1,426 genes were significantly up-regulated in the mutant compared to wt. furthermore, 301 genes were down-regulated with false discovery rates (fdr) of < 0.001 and absolute value of log2 ratio of ≥ 1. results a total of 4,182,944 and 4,182,021 clean tags were obtained from the wt and a nonpathogenic mutant stain (bct89), respectively, and 10,410 differentially ...

Journal: :Transplantation proceedings 2005
A Jain M Orloff P Abt R Kashyap R Mohanka K Lansing M Kelley A Bozorgzadeh

INTRODUCTION With the shortage of donor organs, increasing number of hepatitis B core antibody (HBcAb)-positive [HBcAb(+)] liver allografts are being used for liver transplantation (LTx) in patients who are HBcab-negative [HBsAb(-)]. This study was aimed at assessing outcomes for hepatitis C virus (HCV)-positive [HCV(+)] and HCV-negative [HCV(-)] patients who received HBcAb(+) liver grafts from...

2014
Formijn J. van Hemert Ben Berkhout Hans L. Zaaijer

INTRODUCTION Resistance of the reverse transcriptase (RT) of hepatitis B virus (HBV) to the tenofovir nucleotide drug has not been observed since its introduction for treatment of hepatitis B virus (HBV) infection in 2008. In contrast, frequent viral breakthrough and resistance has been documented for adefovir. Our computational study addresses an inventory of the structural differences between...

2015
Rahim Rahimi Seyed Younes Hosseini Mohammad Reza Fattahi Masood Sepehrimanesh Alireza Safarpour Seyed Ali Malekhosseini Maryam Nejabat Mahboobeh Khodadad Maryam Ardebili

BACKGROUND Recurrence of Hepatitis B Virus infection in patients undergoing liver transplanted (LT) is a serious and often fatal problem. Lamivudine (LAM) and Hepatitis B Immunoglobulin (HBIG) are widely used to manage hepatitis B recurrence after liver transplantation. However, the outcomes in patients are less elucidated. OBJECTIVES The current study aimed to evaluate the YMDD motif mutatio...

2011
Niloofar Neisi Manochehr Makvandi Ali Reza Samarbaf-Zadeh

Introduction and objective: Hepatitis B virus (HBV) is a member of Hepadnaviridae and a major causative agent of chronic and acute hepatitis, liver cirrhosis and hepatocellular carcinoma. Genotype determination of HBV is based on PCR-RFLP and sequencing of genome of the virus. The genotype formation is mainly due to mutations of HBV precore, S, and YMDD (tyrosine-methionine-aspartate-aspartate ...

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