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The possible roles of Src family kinases in the enhanced malignant properties of melanomas related to GD3 expression were analyzed. Among Src family kinases only Yes, not Fyn or Src, was functionally involved in the increased cell proliferation and invasion of GD3-expressing transfectant cells (GD3+). Yes was located upstream of p130Cas and paxillin and at an equivalent level to focal adhesion ...
Social contract theory is incoherent and it does not work as desired. Among the most obvious disanalogies is that contracts are enforced by a third party, commonly the state. There is no such external enforcer for a constitution. Contractarian theorists typically ignore all such issues and use the metaphor of contract very loosely to ground a claim that citizens are morally obligated to defer t...
A 76-year-old woman was admitted for cardiac decompensation, hypertension, and renal failure. To explore her chronic hypertension, urinary fractionated metanephrines were quantified. Fig. 1A shows the chromatogram of the patient’s urine, and Fig. 1B shows the chromatogram of a calibration standard. A very large methoxytyramine peak was observed (Fig. 1A, black arrow). The peak signal was satura...
It is an honor and privilege to address you as president of the American Society for Clinical Investigation. For more than 100 years, this organization has represented the best of physician-scientists. Since it is now 2012, there is the possibility that this could be the last ASCI presidential address. But we will assume the Mayans miscalculated and that we should look to the future. With the A...
Problem Description: It should be well known that processors are outstripping memory performance: specifically that memory latencies are not improving as fast as processor cycle time or IPC or memory bandwidth. Thought experiment: imagine that a cache miss takes 10000 cycles to execute. For such a processor instruction level parallelism is useless, because most of the time is spent waiting for ...
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