Strain L mouse fibroblasts growing in vitro were exposed to varying concentrations of nitrogen and sulfur mustards, and the surviving fraction of cells was measured by their ability to form macroscopically visible colonies. Nitrogen mustard required 3 hours but sulfur mustard less than 1 hour to exert maximum killing effect. The mean lethal dose (D37) for nitrogen mustard acting for 1 hour on a...

Nitrogen mustards alkylate DNA primarily at the N7 position of guanine. Using an approach analogous to that of the Maxam-Gilbert procedure for DNA sequence analysis, we have examined the relative frequencies of alkylation for a number of nitrogen mustards at different guanine-N7 sites on a DNA fragment of known sequence. Most nitrogen mustards were found to have similar patterns of alkylation, ...

Effectiveness of different doses of neem extracts and a synthetic organic insecticide against mustard aphid was studied in the experimental farm of the Oilseed Research Centre, Bangladesh Agricultural Research Institute (BARI), Joydebpur, Gazipur, during two consecutive years 2010-2011 and 2011-2012 for the control of mustard aphid. Eight treatments were evaluated against mustard aphid under fi...

Calcium (Ca) plays important role in plant development and response to various environmental stresses. However, its involvement in mitigation of heavy metal stress in plants remains elusive. In this study, we examined the effect of Ca (50 mM) in controlling cadmium (Cd) uptake in mustard (Brassica juncea L.) plants exposed to toxic levels of Cd (200 mg L(-1) and 300 mg L(-1)). The Cd treatment ...

Objective: To assess long term outcome of patients who underwent Mustard or Senning repair for transposition of the great arteries up to 30 years earlier. Design: Retrospective review of medical records. Setting: The six university hospitals in Belgium with paediatric cardiology departments. Patients: 339 patients were reviewed, of whom 124 underwent the Mustard procedure and 215 the Senning pr...

Transgenic Indian mustard [Brassica juncea (L.) Czern.] plants overproducing the enzymes gamma-glutamylcysteine synthetase (ECS) or glutathione synthetase (GS) were shown previously to have increased levels of the metal-binding thiol peptides phytochelatins and glutathione, and enhanced Cd tolerance and accumulation. Furthermore, transgenic Indian mustard plants overexpressing adenosine triphos...

BACKGROUND AND AIMS The human epidermal growth factor receptor type 2 (HER-2) seems to be sensitive to nitrogen mustard, because nitrogen mustard heavily alkylates on guanine. In this study, we examined the effects of nitrogen mustard on cell growth and expression of HER-2 proteins in cultured human breast cancer cells. METHOD The HER-2 protein levels on the cell surface of breast cancer cell...

A total of 1118 soldiers who were wounded in war and hospitalized in Tehran, were examined for P .versicolor-a superficial mycotic infection. Of these, 213 were war-wounded, 54 chemical (mustard) gas-wounded, 42 both war and chemical gas-wounded, 105 had infectious and noninfectious diseases, and 704 were apparently healthy soldiers serving in war fronts who were examined for P. versicolor...

In this work a novel bioassay for mustard agent detection was proposed. The bioassay is based on the capability of these compounds to inhibit the enzyme choline oxidase. The enzymatic activity, which is correlated to the mustard agents, was electrochemically monitored measuring the enzymatic product, hydrogen peroxide, by means of a screen-printed electrode modified with Prussian Blue nanoparti...

Sulfur mustard (SM), a potent chemical weapon agent, was used by Iraqi forces against Iranian in the Iraq-Iran war (1981-1989). Chronic obstructive pulmonary disease (COPD) is a late toxic pulmonary consequence after SM exposure. The COPD observed in these patients is unique (described as Mustard Lung) and to some extent different from COPD resulted from other well-known causes. Several mechani...