xenograft models

Background: Rearranged during transfection (RET), a transmembrane receptor tyrosine kinase, is involved in multi-system tissue development which includes nervous, hematopoietic, and gastrointestinal systems. Activating RET alteration, induced by gene fusions or point mutations, has been discovered several different solid tumor types including thyroid cancer, non-small cell lung cancer (NSCLC), ...

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New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis

2017

Alexandre Plessier Ludivine Le Dret Pascale Varlet Kévin Beccaria Joëlle Lacombe Sébastien Mériaux Françoise Geffroy Laurence Fiette Patricia Flamant Fabrice Chrétien Thomas Blauwblomme Stéphanie Puget Jacques Grill Marie-Anne Debily David Castel

Diffuse Instrinsic Pontine Glioma is the most aggressive form of High Grade Gliomas in children. The lack of biological material and the absence of relevant models have hampered the development of new therapeutics. Their extensive infiltration of the brainstem renders any surgical resection impossible and until recently biopsies were considered not informative enough and therefore not recommend...

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

2013

Will Sewell Ashley Reeb Reigh-Yi Lin

Several types of animal models of human thyroid carcinomas have been established, including subcutaneous xenograft and orthotopic implantation of cancer cells into immunodeficient mice. Subcutaneous xenograft models have been valuable for preclinical screening and evaluation of new therapeutic treatments. There are a number of advantages to using a subcutaneous model; 1) rapid, 2) reproducible,...

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Enhancement of capecitabine efficacy by oxaliplatin in human colorectal and gastric cancer xenografts.

Journal: :Oncology reports 2007

Noriaki Sawada Kumiko Kondoh Kazushige Mori

We have evaluated the antitumor activity of XELOX (a combination therapy of capecitabine (Xeloda) and oxaliplatin) in human colorectal and gastric cancer xenograft models. In human colorectal cancer model CXF280, antitumor activity of the combination at two-thirds of the maximum tolerated dose (MTD) was superior to that of each monotherapy at MTD. Furthermore, in human colorectal cancer model C...

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Dmm021147 1401..1412

2015

Ceri E. Oldreive Anna Skowronska Nicholas J. Davies Helen Parry Angelo Agathanggelou Sergey Krysov Graham Packham Zbigniew Rudzki Laura Cronin Katerina Vrzalikova Paul Murray Elena Odintsova Guy Pratt A. Malcolm R. Taylor Paul Moss Tatjana Stankovic

Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft models suffer from limited duration of tumour cell engraftment coupled with gradual T-cell outgrowth. Thus, a greater understanding of the interaction...

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نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

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