The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the ...

The reactions of 1 - chloro - 2 - nitro benzene with 2 - Amino thio phenol yield the 2 - ( ( nitro phenyl ) thio ) aniline and then 2 , 2' - thio dianiline of this compound was prepared . Also the symmetrical potentially pentadentate N 2 O 2 S Schiff base ligand 2 , 2' - ( ( ( thio bis (1 , 2 - phenylene ) ) bis ( azanilidene ) ) bis ( methenilidene ) ) diphenol ( H 2 L ) obtain by added salicy...

A new thiosemicarbzone compound was prepared by the reaction of acenaphthenequinone and thiosemicarbazide (1:1 molar ratio) in absolute methanol at 70°C. The crystal structure of this compound, acenaphthenequinone thiosemicarbazone mono methanol, was determined by X-ray crystallography. The unit cell parameters are as follows: a = 7.0384(14) Ǻ, b = 14.202(3) Ǻ, c = 14.270(3) Ǻ, β = 104.26(3)°. ...

Finding the structure of proteins and protein-protein complexes is an important problem in the field of computational biology. Determining protein structures can be done successfully with various experimental methods like x-ray crystallography, but determining protein-protein structures experimentally is more difficult. Instead, these structures are frequently predicted computationally. One app...

In this article, we report a method for coarse-grained normal mode analysis called the minimalist network model. The main features of the method are that it can deliver accurate low-frequency modes on structures without undergoing initial energy minimization and that it also retains the details of molecular interactions. The method does not require any additional adjustable parameters after coa...

Four polymorphs of the bis-phthalocyanine lanthanoid( iii ) double-decker complexes are crystallized by solution evaporation methods, and their structures determined single-crystal X-ray crystallography.

X-ray crystallography has revealed an unusual structural element in kinesin-5 motor proteins.

China has a strong background in X-ray crystallography dating back to the 1920s. Protein crystallography research in China was first developed following the successful synthesis of insulin in China in 1966. The subsequent determination of the three-dimensional structure of porcine insulin made China one of the few countries which could determine macromolecular structures by X-ray diffraction me...

In DNA replication, Okazaki fragments are formed as double-stranded intermediates during synthesis of the lagging strand. They are composed of the growing DNA strand primed by RNA and the template strand. The DNA oligonucleotide d(GGGTATACGC) and the chimeric RNA-DNA oligonucleotide r(GCG)d(TATACCC) were combined to form a synthetic Okazaki fragment and its three-dimensional structure was deter...

Fragment-based drug discovery (FBDD) concerns the screening of low-molecular weight compounds against macromolecular targets of clinical relevance. These compounds act as starting points for the development of drugs. FBDD has evolved and grown in popularity over the past 15 years. In this paper, the rationale and technology behind the use of X-ray crystallography in fragment based screening (FB...