The memory T cell response is polyclonal, with the magnitude and specificity of the response controlled in part by the burst size of T cells expanded from effector/memory precursors. Sensitive assays using HLA class II multimers were used to detect low-frequency Ag-specific T cells directed against influenza viral Ags in subjects immunized with the influenza vaccine. Direct ex vivo tetramer sta...

We previously demonstrated the capacity of the hydroxylamine metabolite of sulfamethoxazole (SMX-HA) to inhibit mitogen-induced T-cell proliferation. We studied the interaction of SMX-HA with the immuno-suppressants cyclosporin A (CsA), FK506 and rapamycin. Human peripheral blood mononuclear leukocytes were treated with SMX-HA and combined in culture with CsA or FK506 or rapamycin. The cells we...

Incorporation of biochar to agriculture field has the potential to be a primary factor in maintaining soil fertility and productivity particularly in nitrogen and organic matter limiting environments however, clear experimental evidence to support this views still lacking. The current experiments were carried out to evaluate the effect of different organic (biochar and FYM) and inorganic amendm...

in order to improve the efficiency of irrigation systems and investigate their impact on the pest population levels, furrow and sprinkler irrigation systems were compared in sugar beet fields. in this study, three different fields were chosen and irrigated by one of the furrow, classic and center pivot irrigation systems.  in each field, 20 plots were randomly selected of which 10 plots were ma...

The present investigation was carried out in the two consecutive years i.e. 2011-12 and 2012-13 at Main Experiment Station, Department of Horticulture, NDUA&T, Faizabad, (U.P.). The experiment was conducted in RBD replicated four times with twelve treatments. The treatments involved in the study were 12 in numbers i.e. FYM in six different doses (0, 05,10,15,20 and 25 t/ha) and nitrogen through...

Purpose: PARP1/2 inhibitors are a class of anticancer agents that target tumor-specific defects in DNA repair. Here, we describe BMN 673, a novel, highly potent PARP1/2 inhibitor with favorable metabolic stability, oral bioavailability, and pharmacokinetic properties. Experimental Design: Potency and selectivity of BMN 673 was determined by biochemical assays. Anticancer activity either as a si...

Biochemical parameters of the histamine (HA) system were examined in both rat brain and stomach, after portocaval anastomosis (PCA). These tissues become rich in histamine after PCA. Immunocytochemistry was used for brain histamine localisation. In addition to increased HA concentrations, monoamine oxidase B activity increased in both tissues. In hypothalamus HA was 15 fold; in cerebral cortex ...