Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy. This study evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic, and transcriptional features of healing. Three full-thickness cutaneous wounds were created on each distal forelimb in six healthy horses, fo...

BACKGROUND Ischemic ulcerations of the distal lower extremities are a manifestation of chronic critical limb ischemia. Without restoration of arterial flow, subsequent gangrene and limb loss can ensue. Unfortunately, revascularization is not always possible. METHODS A literature search of MEDLINE was performed and a case series of 5 patients with lower extremity ischemic ulcerations is descri...

Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times. OBJECTIVE The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and...

conclusions the designed safe irrigator syringe seems to be applicable in wound irrigation and superior to the conventional devices regarding efficacy and user comfort. results all of the interns stated that the new device is quite applicable for wound washing and is easy to handle. nine interns believed that safe irrigator syringe is superior to the conventional devices regarding efficacy and ...

a chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time or wounds that do not heal within three months are often considered chronic. chronic wounds often remain in the inflammatory stage for too long and may never heal or may take years. chronic wound patients often report pain as dominant in their lives. persistent pain is the main problem ...

A review of randomized controlled trials and observational cohort studies found in the PubMed, Embase, Cochrane databases through April 2021. In 26 comprising 26,845 patients who were treated by uncoated balloon (UCB) (17,770) or drug-coated (DCB) (9075) angioplasty for lower extremity peripheral arterial disease (LE-PAD), DCB was associated with significantly vessel restenosis, reduction major...

in the present investigation, methanolic extract of mimusops elengi  leaves were evaluated for wound healing activity. entire wound healing process is complex series of events that begins at the moment of injury and can continue for months to years. methanolic extract of mimusops elengi leaves were examined for wound healing activity in the form of ointment by the excision, the incision and dea...

discussion the prevalence of mtss was relatively lower in this study comparing to other studies on military personnel. it was not probably due to type of military shoes or exercise area surface (none of them were standardized); it could be due to low intensity trainings and the long intervals between training sessions. results data of all the 181 subjects with the mean age of 30.7 ± 4.68 years ...

background selection of anesthetic approach for lower extremity operations is often a controversial issue for anesthesiologists. objectives the aim of this study was to compare the incidence and severity of back pain between general and spinal anesthesia, and to find effective factors in developing postoperative back pain. patients and methods in a randomized clinical trail, 148 patients with e...

RESULTS: The majority of flaps were for lower extremity trauma wounds (74), followed by upper extremity trauma wounds (8), scalp tumor defects (4), and one torso wound. There were 7 flap losses, but of these, 4 were due to noncompliance with postoperative immobilization/elevation orders; excluding these 4 failures for which the NPD was clearly not a factor, the flap success rate was 96.4%. Skin...