transfusion-dependent patients such as those suffering from β-thalassaemia develop a fatal secondary haemosiderosis and consequently a selective iron chelator must be used to relieve such iron overload. 3- hydroxypyridin-4-ones are selective for iron(iii) under most biological conditions, but unlike desferrioxamine, are efficiently absorbed when administered orally. in this study, the synthesis...

iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...

background: patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. the aim of this study was to compare effect of combined versus monotherapy with deferoxamine (dfo) and deferiprone (dfp) in iron overloaded beta thalassemia (bt) major patients materials and methods we studied 36 bt major patients (mea...

forty two small ruminants, 26 (61.90%) sheep and 16 (38.10%) goats were treated for rumen acidosis. 19 (45.24%), 12 (28.57%), 6 (14.29%) and 5 (11.90%) animals had eaten apple, cooked rice (wazwan left over) turnip and chapatti respectively and manifested clinical form of ruminal acidosis with, 2.86%; (n=18) as mild (rumen fluid ph=6.32 ±0.09316), 38.09%;(n=16)moderate (rumen fluid ph=5.71 ±0.0...

Work-overload on employees is generally caused by the irrelevant basic education they already have, so that many of them work not according to competence. Of 98 employees, 22 have attended training. Some still more than working hours every month. This has a bad impact performance which causes come late The purpose this study determine whether work-overload positive effect employee performance. ...

The article deals with the problems of technostress in implementation digital technologies. main types techno-stresses when using technologies (techno-overload, techno-anxiety, techno-invasion, techno-complexity, techno-uncertainty) are identified and their causes revealed. It is shown that intensive work tools accompanied by a number undesirable consequences (cognitive overload, emotional dist...

Like most essential nutrients, Fe needs to be maintained in the body at a defined level for optimal health, with appropriate adaptation to varying Fe needs and supply. The primary mechanism for controlling Fe level is the regulation of Fe absorption. Several different proteins have been identified as contributors to the process. Despite a complex regulatory system, Fe disorders (both Fe deficie...

isolated rat hepatocytes in culture were incubated with different concentrations of iron-sorbitol (50, 100, 150, and 200 µm) to assess the changes in reactive oxygen species (ros) and lipid peroxidation leading to apoptotic hepatocyte cell death. the viability of hepatocytes was declined depending on the iron concentration. one hour incubation of the cells with 100 µm iron resulted in decreased...

background: sickle-cell anemia is characterized by defective hemoglobin synthesis with production of sickle hemoglobin. sickle red blood cells become deformed and rigid with difficulty to pass through narrow capillaries and frequent clotting and thrombosis leading to repetitive vascular occlusions and progressive organ damage. we conducted this work to study some adrenal functions using acth st...

In this work, the practical problem of frequent-itemset discovery in data-stream environments which may suffer from data overload. The main issues include frequent-pattern mining and data-overload handling. Therefore, a mining algorithm together with Separate dedicated overload-handling mechanisms is proposed. The algorithm DBCA (Dynamic Base Combinatorial Algorithm) extracts basic information ...