We derive an efficient CH-type inequality. Quantum mechanics violates our proposed inequality independent of the detection-efficiency problem. In photonic Bell-type experiments [1], when photon pairs with parallel linear polarizations are emitted, one can consider a Clauser-Horne (CH) inequality [2], at the level of hidden variables, in the form − 1 ≤ Srq,HV (â, b̂, â, b̂, λ) ≤ 0 (1) where Srq,HV...

The relationship between DNA topoisomerase II activity and drug resistance was studied in cloned cell lines of Adriamycin (ADR)-sensitive and -resistant P388 leukemia; drug resistant P388/ADR/3 (clone 3) and P388/ADR/7 (clone 7) cells are 5and 10-fold more resistant to ADR than the sensitive cell line P388/4 (Cancer Res., 46: 2978, 1986). Topo isomerase II catalytic activity in crude nuclear ex...

Piritrexim, a new nonclassical antifolate, was evaluated in a multiinstitutional phase I trial in children. The starting dose was 290 mg/m2/ day, administered p.o. every 12 h for 5 consecutive days, with courses repeated every 21 days. Dose reduction, initially to 200 mg/m2/day and subsequently to 140 mg/m2/day, was required because dose limiting myelosuppression and mucositis were encountered ...

A 42 year old man without familial adenomatous polyposis had recurrent desmoid tumours in the left subclavicular site. Histological examination showed a typical desmoid tumour. Molecular analysis was performed in genomic DNA from this tumour, using polymerase chain reaction– single strand conformation polymorphism (PCR-SSCP) and direct sequencing methods. No mutation could be detected in the en...

In 1968, Marshall and Johnson settled a long-standing structural problem with â-vetivone, firmly establishing it as 1 by synthesis.1 Previously, â-vetivone was considered to be a bicyclic R,â-unsaturated ketone possessing a hydrazulene framework, interpretive of its dehydrogenation to give vetivazulene. The interpretive error arose from the assumption that the dehydrogenation occurred without s...

The effect of a long-acting somatostatin analogue SMS 201.995 (SMS; Sandoz) on basal and gastrin-stimulated growth of 4 human colon cancer lines was studied in vitro and in vico. Proliferation assay was done with overnight |75Se|selenomethionine uptake after 5 days of incubation. Gastrin concentrations used were 5e-10 M and le-7 M. SMS concentrations were from 2e-12 M to 2e-7 M. Cell lines LIM ...