30 Controversy exists about whether one-dimensional (1D) wave theory can explain the ‘self31 cancelling’ waves that accompany the diastolic pressure decay and discharge of the arterial 32 reservoir. Although it has been proposed that reservoir and wave effects be treated as separate 33 phenomena, thus avoiding the issue of self-cancelling waves, we have argued that reservoir 34 effects are a ph...

Abstract Aortic dissection (AD) is one of the fatal and complex conditions. Since there a lack specific treatment guideline for type-B AD, better understanding patient-specific hemodynamics therapy outcomes can potentially control progression disease aid in clinical decision-making process. In this work, geometry AD reconstructed from computed tomography images, numerical simulation using perso...

Atherosclerosis of lower extremity is often accompanied by thrombosis and plaque injury. Currently, there a lack comprehensive hemodynamics study that combines platelet activation related to injury in atherosclerosis. Thus, we first analyze the mechanism further investigate effects stenosis hematocrit through hemodynamic results. An Euler–Euler method used for mixed fluid containing red blood c...

We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood viscosity, and blood density. A three-element windkessel represented the distal arterial tree. Sensitivity analysis was performed in terms of ...

Aortic impedance, wave reflection magnitude, and compliance were measured in patients with Marfan's syndrome during diagnostic cardiac catheterization. Impedance and wave reflections were calculated from standard Fourier series analysis of ascending aorta micromanometer pressure and electromagnetic flow records. Compliance was estimated by a method recently proposed that uses the area under the...

Study of Arterial pressure and flow variation when external pressure applied is critical in understanding clinical relevance of pulse. We propose a distributed model of entire human arterial tree to describe the hemodynamic changes due to pressure applied on the brachial artery. Input to this distributed model is from a four element Windkessel model. We measured the blood volume during brachial...

1. The effects of ovariectomy (Ovx), menopause and oestrogen replacement on the haemodynamics remain controversial. The present study employed the technique of arterial impedance analysis to measure and calculate the steady and pulsatile haemodynamics. The purpose was to determine the haemodynamic consequence of ovariectomy and oestrogen replacement. 2. Ovariectomy was carried out under anaesth...

BACKGROUND Prosthetic replacement of the ascending aorta with nonelastic vascular grafts impairs the local Windkessel function. Whether this increases wall tension in the remaining aorta is still a not completely investigated hypothesis but is of clinical relevance with respect to postprocedural development of aneurysms and dissections, especially in the proximal descending aorta. METHODS Fre...

The goal of this study was to review the origin, clinical relevance and treatment of pulse pressure (PP). Elevated PP is increasingly being recognized as a risk factor for cardiovascular, particularly coronary, disease. Pulse pressure is discussed in terms of both Windkessel and distributive models of the arterial circulation. Pulse pressure arises from the interaction of cardiac ejection (stro...

Cardiovascular diseases are one of the major problems in medicine today and the number of patients increases worldwide. To find the most efficient treatment, prior knowledge about function and dysfunction of the cardiovascular system is required and methods need to be developed that identify the disease in an early stage. Mathematical modeling is a powerful tool for prediction and investigation...