Meta-analysis helps to find final objective evaluation for the research’s field, which includes all accumulated data. Therefore, that provides a unique perspective to see whole picture. As example, one of the recent meta-analysis of circulation research collected 872 articles along 27 years without any language restriction, which considered of interest and fully reviewed. However, 16 eligible a...

Heart and vascular defects occur in a large number of hereditary and sporadic human diseases as a result of a complex interplay of genetic factors. Since genome sequencing of many organisms disclosed similarities among genomes, animal models are crucial for the discovery of genes involved in those pathological processes. Therefore we propose a VRG database, in which human data have been manuall...

The following omissions and errors in the entries up to the end of 1994 have come to light so far.

Despite the small sample size that often complicates research into diseases that affect children, recent genome sequencing efforts have made astounding progress in discovering the underlying genetic causes of pediatric diseases, many of which were previously unpredicted. This Select highlights recent genetic findings that provide clear insights into disease mechanisms and therapeutic targets th...

This unit describes how to use the Parallel Contig Assembly Program (PCAP) to assemble the data produced by a whole-genome shotgun sequencing project. We present a basic protocol for using PCAP on a multiprocessor computer in a 300-Mb genome assembly project. A support protocol to prepare input files for PCAP is also described. Another basic protocol for using PCAP on a distributed cluster of c...

The UK's 100,000 Genomes Project has the aim of sequencing 100,000 genomes from UK National Health Service (NHS) patients while concomitantly transforming clinical care such that whole genome sequencing becomes routine clinical practice in the UK. Policymakers claim that the project will revolutionize NHS care. We wished to explore the 100,000 Genomes Project, and in particular, the extent to w...

Overview Comparative genome sequencing has the greatest impact on biology when the targeted genomes impinge directly on analysis or interpretation of the human genome or the genome of a genetic model system. Comparative genomics may also shed light on the genetic and evolutionary mechanisms that determine genome organization and composition. The most obvious benefit of comparative genomics has ...