نتایج جستجو برای: white matter wm
تعداد نتایج: 372237 فیلتر نتایج به سال:
The work presented in this thesis employed magnetic resonance imaging (MRI) techniques to determine the volume and metabolite profile of brain grey matter (GM) and white matter (WM) in people with clinically early relapsingremitting m ultiple sclerosis (MS). C ross-sectional MRI and clinical data was obtained from 27 subjects with relapsing-remitting MS within 3 years of first symptom onset, an...
We have measured the pharmacokinetics of three retinoids, all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in rat blood and rat brain [especially white matter (WM) and gray matter (GM)] to help select retinoids for treating human malignant glioma. All-trans retinoic acid permeated well into the WM, giving peak concentration in WM of 25.7 microg/g, 6 to 7 times higher than the peak...
Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic...
BACKGROUND Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease. OBJECTIVES To use volumetric MRI techniques to identify the patterns of WM atrophy in vivo in 2 clinical variants of frontotemporal lobar degeneration-fro...
BACKGROUND AND PURPOSE In acute ischemic stroke, white matter (WM) is considered more resistant to infarction than gray matter (GM). To test this hypothesis, we compared the fate of WM and GM voxels belonging to the acute diffusion-weighted imaging (DWI) lesion, expecting WM voxels to be more prone to reversal after thrombolysis. METHODS Reversible acute DWI (RAD) lesion was defined voxel-wis...
BACKGROUND Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS). OBJECTIVE To study whether subpial cortical demyelination in MS is associated with focal or diffuse white matter (WM) pathologic features on magnetic resonance imaging (MR imaging). DESIGN Comparison of postmortem MR imaging findings with histopathologic finding...
Introduction: Diffusion tensor imaging (DTI) is widely used for the study of white matter (WM) diseases and fractional anisotropy (FA) is commonly used as a measure of WM integrity. However, FA is also highly sensitive to such factors as non-Gaussian diffusion, crossing fibers and imaging noise, which may impair its specificity. Other DT measures, such as axial diffusivity (Da) and radial diffu...
The estimation of cortical thickness is in part dependent on the degree of contrast in T1 signal intensity between white matter and gray matter along the cortical mantle. The ratio of white matter to gray matter signal (WM/GM contrast) has been found to vary as a function of age and Alzheimer's disease status, suggesting a biological component to what might otherwise be labeled as a nuisance va...
Diffusion tensor imaging (DTI) is a recent magnetic resonance (MR) technique that provides comprehensive information about water diffusivity. Since diffusivity correlates with tissue structure at the microscopic level DTI reveals fibrous structures such as white matter (WM) pathways in the field of neurosurgery. WM tracts are thereby of major interest and the ability to distinguish between diff...
The present study combined behavioral measures and diffusion tensor imaging to investigate the neuroanatomical basis of language learning in relation to phonological working memory (WM). Participants were exposed to simplified artificial languages under WM constraints. The results underscore the role of the rehearsal subcomponent of WM in successful speech segmentation and rule learning. Moreov...
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