Previous studies in the field of acid-base and oxidative status cows have mainly focused on transition period (three weeks before three after calving). The aim this study was to determine differences parameters electrolyte balance not only during period, but also at other stages production cycle. Holstein-Friesian were divided into four numerically equal groups (n = 6): early lactating (9?2 day...

Swelling-activated or volume-sensitive Cl- currents are found in numerous cell types and play a variety of roles in their function; however, molecular characterization of the channels is generally lacking. Recently, the molecular entity responsible for swelling-activated Cl-current in cardiac myocytes has been identified as ClC-3. The goal of our study was to determine whether such a channel ex...

BACKGROUND Intravenous plasma administration has been recommended in healthy or sick calves with failure of passive immunity. HYPOTHESIS IV administered plasma-derived immunoglobulin G (IgG) undergoes increased catabolism as reflected by a rapid decrease in serum IgG concentration with an increase in fecal IgG concentrations within 48 h. ANIMALS Thirty newborn Jersey calves. Fifteen were fe...

The aim of this study was to evaluate the effect of augmented renal clearance (ARC) on vancomycin serum concentrations in critically ill patients. This prospective, single-centre, observational, cohort study included 93 consecutive, critically ill septic patients who started treatment that included vancomycin by continuous infusion, admitted over a 2-year period (March 2006 to February 2008). A...

region πa2 (26,50) πa1 (13,98) Figure 7 – Phase Transition curves in (L,m) and (N,L) plane with the useful area for abstraction Ideally, if a ground problem lies in the mushy region and has solution, then a useful abstraction operator shall map it into an abstract problem lying in the YES region. On the contrary, if a ground problem lies in the mushy region and has no solutions, then a useful a...

The objective of this study was to examine the interrelationships between maternal and fetal plasma drug protein binding, umbilical blood flow (Q(um)), gestational age (GA), and maternal-fetal diphenhydramine (DPHM) clearances in chronically instrumented pregnant sheep. Maternal and fetal DPHM placental (CL(mf) and CL(fm), respectively) and nonplacental (CL(mo) and CL(fo), respectively) clearan...

Chloride (Cl(-)) homeostasis is critical for many cell functions including cell signaling and volume regulation. The action of GABA at GABA(A) receptors is primarily determined by the concentration of intracellular Cl(-). Developmental regulation of intracellular Cl(-) results in a depolarizing response to GABA in immature neocortical neurons and a hyperpolarizing or shunting response in mature...