The nuclease halo mutant, nuh-4, of Neurospora crassa was identified conclusively as an allele of uvs-3, a gene involved in error-prone DNA repair. Like uvs-3, nuh-4 showed spontaneous mutator effects, and any previous contradictory findings were found to be due to newly arisen mutants. In normal strains the two alleles are noncomplementing and indistinguishable for sensitivity to UV and methyl...

introduction systemic lupus erythematosus (sle) is a complex autoimmune and inflammatory disease. many studies show hla alleles can be associated with sle. the aim of this study was to determine the association of hla-drb1 alleles with juvenile- onset in iranian children. materials and methods at a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to ...

background: a common human leukocyte antigen (hla) class ii allele, dqβ1*03:01, seems to be associated with bullous pemphigoid (bp) in caucasians whereas previous studies in other ethnic groups showed other hla class ii alleles as genetic predisposing factors for bp. objective: to investigate the association of hla class ii alleles and haplotypes with bp in iranian population. methods: fifty pa...

BACKGROUND Gilbert's syndrome is a chronic or recurrent mild unconjugated hyperbilirubinemia caused by decreased activity of UDP glucuronosyltranferase (UGT1A1). The most common cause of Gilbert's syndrome in Caucasians is homozygous variant of the A(TA)7TAA promoter polymorphism. Alleles with five or eight TA repeats have also been described, but they are very rare in Caucasian populations. ...

Resistance to pathogens has been measured directly in several organisms by examining single-copy major histocompatibility complex (MHC) genes (1, 2). However, some MHC genes are found in multiple, tightly linked copies, as expected from gene duplication. Wegner et al. (3) reported that for a class IIB MHC gene with a variable number of copies (three to nine copies in different individuals) in t...