Patterning and proliferation are coordinately controlled in the development of Drosophila imaginal discs. Localized expression of decapentaplegic (dpp) at the anterior-posterior and wingless (wg) at the dorsal-ventral compartment boundaries controls growth of the wing with respect to the A/P and D/V axes. The growth-promoting effects of these organizers are thought to be indirect, since growth ...

A Drosophila homolog of the serine/threonine kinase GSK-3 beta, encoded by the zest-white3/shaggy gene (zw3), has been implicated as a maternally provided antagonist of zygotic signaling by the secreted segmentation gene wingless (wg). The wg signal apparently causes a spatially localized inhibition of the ubiquitous repressor function of zw3. This double negative mechanism of signal transducti...

It is known that if P is either the property w-bounded or countably compact, then for every cardinal a 2 w there is a P-group G such that H.G = a and no proper, dense subgroup of G is a P-group. What happens when P is the property pseudocompact? The first-listed author and Robertson have shown that every zero-dimensional Abelian P-group G with H.G > o has a proper, dense, P-group. Turning to th...

BACKGROUND Diagnosis of active pulmonary and paranasal involvement in patients with Wegener's granulomatosis (WG) can be difficult. The diagnostic value of gallium-67 scintigraphy in WG is unclear. OBJECTIVE To evaluate the added diagnostic value of gallium-67 scintigraphy in patients with WG with suspected granulomatous inflammation in the paranasal and chest regions. METHODS Retrospective...

We report on a patient with biopsy proven systemic Wegener's granulomatosis (WG) with a granulomatous necrotising manifestation of WG in the liver, lung, parotid gland and skin with subsequent death of liver failure. Liver involvement in WG is an exceedingly rare, though potentially fatal, organ manifestation of WG.

*System Devices Research Laboratories †System Platforms Research Laboratories Two types of waveguide photodiodes (WG-PD)  an evanescently coupled photodiode (EC-WG-PD) and a separated-absorption-and-multiplication avalanche photodiode (WG-APD)  were developed for use in 40Gbps receivers. The EC-WG-PD is much more robust than a conventional WG-PD under high optical input operation because of i...

Wingless (Wg) signalling regulates the expression of its target genes through Pangolin, Armadillo and their interacting co-factors. In a genetic screen for Wg signalling components, we found that imitation switch (ISWI), a chromatin-remodelling ATPase, had a positive role in transducing the canonical Wg signal, promoting the expression of the Wg target senseless. ISWI is found in several chroma...

The segment polarity gene cubitus interruptus (ci) encodes a transcriptional effector of Hedgehog (Hh) signaling in Drosophila. The Ci gene product is a zinc finger protein belonging to the Gli family of sequence-specific DNA binding proteins. After gastrulation, segmental expression of the segment polarity gene wingless (wg) is maintained by Hh signaling in a pathway requiring Ci activity. In ...

PURPOSE To report a case of central retinal artery occlusion (CRAO) in a patient with biopsy-verified Wegener's granulomatosis (WG) with positive C-ANCA. METHODS A 55-year-old woman presented with a 3-day history of acute painless bilateral loss of vision; she also complained of fever and weight loss. Examination showed a CRAO in the left eye and angiographically documented choroidal ischemia...

The weak Galerkin (WG) methods have been introduced in [11, 16] for solving the biharmonic equation. The purpose of this paper is to develop an algorithm to implement the WG methods effectively. This can be achieved by eliminating local unknowns to obtain a global system with significant reduction of size. In fact this reduced global system is equivalent to the Schur complements of the WG metho...