Voltage-gated Kv7 channels are inhibited by agonists of Gq-protein-coupled receptors, such as histamine. Recent works have provided evidence that inhibition of vascular Kv7 channels may trigger vessel contractions. In this study, we investigated how Kv7 activity modulates the histamine-induced contractions in "healthy" and metabolic syndrome (MetS) pig right coronary arteries (CAs). We performe...

Renal afferent arterioles (Aff) from angiotensin II (AngII)-infused rabbits have enhanced contractions to AngII that are normalized by tempol (superoxide dismutase mimetic), whereas contractions to norepinephrine (NE) are normal and unaffected by tempol. Tested was the hypothesis that beta-receptor stimulation with NE prevents enhanced reactivity and superoxide generation. Preconstricted Aff fr...

Prolonged and weak isometric contractions can result in neuromuscular fatigue. Alternation of discharge of motor units with similar thresholds (termed rotation) could be useful to minimize neuromuscular fatigue by providing periods for metabolic recovery of the contractile elements. In the present study, we investigated the prevalence of motoneuron rotation during prolonged contractions of dist...

1. The reflex effect of direct mechanical stimulation of the exposed ampulla of the horizontal canal has been graphically recorded for each of the six extrinsic muscles of the eyeball. 2. Stimulation of a horizontal ampulla evokes a strong contraction of the homolateral rectus internus and of the contralateral rectus externus; at the same time the homolateral rectus externus and the contralater...

PURPOSE To investigate the relationship between displacement of pelvic floor landmarks observed with transperineal ultrasound imaging and electromyography of the muscles hypothesised to cause the displacements. MATERIALS AND METHODS Three healthy men participated in this study, which included ultrasound imaging of the mid-urethra, urethra-vesical junction, ano-rectal junction and bulb of the ...

In this paper, the notion of θ*-weak contraction is introduced, which utilized to prove some fixed point results. These results are helpful give a positive response certain open question raised by Kannan and Rhoades on existence contractive definition does not force mapping be continuous at point. Some illustrative examples also given support our As applications result, we investigate uniquenes...