نتایج جستجو برای: wasp sting
تعداد نتایج: 8691 فیلتر نتایج به سال:
The present review article explains the salient features of hornet venom toxins, their physiological, biological and pharmacological effect on animals man. Hornets sting very fast inflict venom, which is more dangerous than those bees. Hornet contains both proteinaceous non-proteinaceous peptides i.e. scapin, adolapin, mellitin, mastoparans enzymes, mainly phospholipase hyaluronidase, show mult...
Stimulator of interferon genes (STING) is an important regulator of the innate immune response to cytoplasmic DNA. However, regulation of STING itself is largely unknown. Here, we show that STING transcription is induced by innate immune activators, such as cyclic dinucleotides (CDNs), through an IFNAR1- and STAT1-dependent pathway. We also identify a STAT1 binding site in the STING promoter th...
Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate immune responses. However, the role of STING in adaptive immunity is still unknown. In this study, we show that STING activation reduces the proliferation of T lymphocytes. This activity was independent of TBK1 and IRF3 recruitment and of t...
Background and purpose: Scorpion envenomation is a serious health problem in tropical and subtropical regions. There are several reports on scorpion stings in Kazerun, Iran, therefore, the present study was conducted to establish a strategy to reduce the rate of scorpion sting. Materials and methods: The study was conducted in 2009 to 2014. Relevant information was collected from Kazerun hea...
An idealised modelling study of sting-jet cyclones is presented. Sting jets are descending mesoscale jets that occur in some extratropical cyclones and produce localised regions of strong low-level winds in the frontal fracture region. Moist baroclinic lifecycle (LC1) simulations are performed with modifications to produce cyclones resembling observed sting-jet cyclones. A sting jet exists in t...
Recognition of human cytomegalovirus (HCMV) DNA by the cytosolic sensor cGAS initiates STING-dependent innate antiviral responses. HCMV can antagonize host immune responses to promote latency infection. However, it is unknown whether and how HCMV targets the cGAS-STING axis for immune evasion. Here we identified the HCMV tegument protein UL82 as a negative regulator of STING-dependent antiviral...
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to ...
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate immune responses to DNA virus infection. Although ubiquitination is essential for STING function, how the ubiquitination/deubiquitination system is regulated by virus infection to control STING activity remains unknown. In this study, we found that USP21 is an important deubiquitinating enzyme for STING and th...
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