STUDY DESIGN This study is to investigate the intraradicular inflammation induced by mechanical compression using in vivo model. OBJECTIVES The relationship between the intraradicular edema and nerve fiber degeneration induced by mechanical compression was determined in the nerve root. SUMMARY OF BACKGROUND DATA Recently some studies reported that mechanical compression increased microvascu...

If a peripheral nerve is cut, that portion of the nerve distal to the point of section undergoes a series of changes characteristic of Wallerian degeneration. Logan, Mannell & Rossiter (1952 a) showed that in the peripheral segment of the sciatic nerve of the cat degenerating after nerve section there is an increase in the concentration of nucleic acid. This change, which is probably related to...

Axon and synapse degeneration are common components of many neurodegenerative diseases, and their rescue is essential for effective neuroprotection. The chimeric Wallerian degeneration slow protein (Wld(S)) protects axons dose dependently, but its mechanism is still elusive. We recently showed that Wld(S) acts at a non-nuclear location and is present in axons. This and other recent reports supp...

W degeneration is a well-known entity which represents distal axonal degeneration and myelin disintegration following interruption of any axon from its cellular connection. It was first described by Weller in 1850 and is named after him.1 It is well described entity on imaging in brain but is less well described in spinal cord with only few reports in radiological literature and in post mortem ...

Electron microscopic findings on the nerve of the biventer cervicis muscle of the chick, which was completely transected and immediately after submitted to an adequate microsurgical nerve suture, confirmed our previous statement that proper microsurgical nerve suture may impede the Wallerian degeneration that normally occurs in the distal segment of a completely transected nerve.

degeneração Cerebelar SeCundária à intoxiCação aguda por Carbonato de lítio Pedro Ernesto University Hospital of the University of the State of Rio de Janeiro (HUPE/UERJ): Neurology Service at the State University of Rio de Janeiro RJ, Brazil; Psychiatry Service at the State University of Rio de Janeiro RJ, Brazil; Institute of Psychiatry at the Federal University of Rio de Janeiro (IPUB / UFRJ...

Fragments of injured axons that detach from their cell body break down by the molecularly regulated process of Wallerian degeneration (WD). Although WD resembles local axon degeneration, a common mechanism for refining neuronal structure, several previously examined instances of developmental pruning were unaffected by WD pathways. We used laser axotomy and time-lapse confocal imaging to charac...

Local axon degeneration is a common pathological feature of many neurodegenerative diseases, whereas the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of Rho. Nogo-66, a myelin-derived inhibitor of axon regeneration, significantly accelerated axon d...