Changes in intracellular free calcium concentration ([Ca2+]i) are known to influence a variety of events in developing neurons. Although spontaneous changes of [Ca2+]i have been examined in immature cortical neurons, the calcium dynamics of cortical precursor cells have received less attention. Using an intact cortical mantle and confocal laser microscopy, we examined the spatiotemporal pattern...

Fibroblast growth factor receptor 1 (Fgfr1) is expressed at high levels by progenitor cells of the ventricular zone (VZ) within the hippocampal primordium. To investigate the role of Fgfr1 in these cells, in vivo Cre recombination of "floxed" Fgfr1 alleles was directed to cells of the radial glial lineage by using the human glial fibrillary acidic protein promoter. Radial glial-like cells of th...

This study characterized guaifenesin pharmacokinetics in children aged 2 to 17 years (n = 40) who received a single oral dose of guaifenesin (age-based doses of 100-400 mg) 2 hours after breakfast. Plasma samples were obtained before and for 8 hours after dosing and analyzed for guaifenesin using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using non...

While several major classes of neocortical neural precursor cells have been identified, the lineal relationships and molecular profiles of these cells are still largely unknown. Furthermore, the individual contribution of each cell class to neocortical growth during normal development and in neurodevelopmental disorders has not been determined. Using a novel fate-mapping approach, we demonstrat...

Welchman et al. (1) propose a Bayesian model that combines a velocity prior for slow motion (2, 3) with approximations of lateral velocity Vx and velocity in depth Vz to model biased perception of 3D motion trajectories in the x–z plane (3, 4). Although decomposing a motion vector into orthogonal components may be mathematically convenient it raises the question of why the visual system should ...

Singularity based on fractal and multifractal is a technique for detection of depletion and enrichment for geochemical exploration, while the index of vertical geochemical zonality (Vz) of Pb.Zn/Cu.Ag is a practical method for exploration of blind porphyry copper mineralization. In this study, these methods are combined for recognition, delineation, and enrichment of Vz in Jebal- Barez in the s...

Objective: It is important to improve caregiving skills help reduce the strain on inexperienced caregivers. Previous studies quantifying have predominantly relied expensive equipment, such as motion-capture systems with multiple infrared cameras or acceleration sensors. To overcome cost and space limitations of existing systems, we developed a simple evaluation system for transfer care that use...

singularity based on fractal and multifractal is a technique for detection of depletion and enrichment for geochemical exploration, while the index of vertical geochemical zonality (vz) of pb.zn/cu.ag is a practical method for exploration of blind porphyry copper mineralization. in this study, these methods are combined for recognition, delineation, and enrichment of vz in jebal- barez in the s...

We present the first time/space analysis using in situ hybridization for PTTG and prc1 genes during development of the mouse telencephalon. During the stages E11.5-E13.5 PTTG and prc1 are expressed in most tissues of the embryo. Within the telencephalon, PTTG and prc1 are found exclusively inside of the ventricular zone (VZ). The intensity of the expression of both genes in the ventricular zone...

Studies of the effects of endocrine-disrupting compounds (EDCs) on invertebrates are still largely underrepresented. This work aims to fill this gap by assessing the effects of bisphenol A (BPA) and vinclozolin (Vz) on the terrestrial isopod Porcellio scaber (common rough woodlouse). Male adult and sexually undifferentiated juvenile woodlice were exposed to the toxicants. Effects on molting reg...