THE PATIENT was a 77-year-old female who initially underwent radical vulvectomy with bilateral inguinal lymphadenectomy for classification of the International Federation of Gynaecologists and Obstetricians stage III squamous cell carcinoma of the vulva. At the time of the original treatment, there was no evidence of systemic spread of disease. Over the following 6 months, the patient developed...

Gynecologic cancer mainly consists of three major tumors; endometrial carcinoma, ovarian carcinoma, and uterine cervical carcinoma, and also includes vulvar carcinoma. Most patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-II early-stage gynecologic cancer achieve a favorable clinical outcome with surgery alone or with surgery plus postoperative adjuvant chemoth...

Background and purpose Describe the survival rates and distribution of events on competing failure types in vulvar carcinoma after treatment with chemoradiation (CRT) or radiation (RT) alone. Material and methods We included patients with vulvar carcinoma treated with CRT or RT between 2009 and 2014. Survival was estimated using the Kaplan-Meier method. We performed a competing risk analysis ...

Vulvar cancer is a relatively rare disease. The aim of this study was to investigate prognostic factors in vulvar squamous cell carcinoma patients treated with primary surgery. Forty cases of vulvar squamous cell carcinoma treated with primary surgery were retrospectively analyzed. Overall survival (OS) and disease-specific survival (DSS) were calculated using the Kaplan-Meier method and progno...

1. Knopp S, Bjorge T, Nesland JM, Trope C, Scheistroen M, Holm R. p16INK4a and p21Waf1 ⁄ Cip1 expression correlates with clinical outcome in vulvar carcinomas. Gynecol. Oncol. 2004; 95; 37–45. 2. Knopp S, Bjorge T, Nesland JM, Trope C, Holm R. Cyclins D1, D3, E, and A in vulvar carcinoma patients. Gynecol. Oncol. 2005; 97; 733–739. 3. McKay JA, Douglas JJ, Ross VG et al. Expression of cell cycl...

Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal (n = 66) and ...

Japan has a lower incidence of vulvar squamous cell carcinoma (VSCC) than Western nations. To pin-point the reasons for this, we reviewed biopsy samples from all cases treated at Nagoya University Hospital over the past 33 years in order to investigate the background lesions for VSCC. Two of 36 VSCC patients had adjacent or coexisting lichen sclerosus (LS), 5 had squamous cell hyperplasia (SCH)...

In 2008, CDC published a supplement to the journal Cancer describing incidence patterns of human papillomavirus (HPV)-associated cancers prior to availability of an HPV vaccine. This report updates the information on HPV-associated female genital cancer incidence with more recent data, adds information on trends, and includes American Indian/Alaska Native (AI/AN) populations. We used combined d...

vulvar liposarcoma is rare and there are only eleven cases reported since 1966.primary sarcoma of the vulva constitutes 1-2% of all vulvar malignancies.Because of their locations and appearance,they may be easily mistaken as bening lesions.this is a report of a 65-years-old wite a vulvar mass similar to a lipoma.the lesion,a soft tissue mass,was totally excised and was sent for pathologic study...

Two types of gynecologic tumors are commonly described in the Turner syndrome, the first one is gonadoblastoma, which occurs in patients with Y chromosome abnormalities, and the second one is endometrial carcinoma which is mostly related with exogenous estrogen usage. Here, we describe an extremely rare case of squamous cell carcinoma of the vulva in a virgin woman with Turner syndrome. A 35-ye...