Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin diseases, hardly penetrates into and through the skin owing to its high hydrophobicity and molecular weight. The aim of this study was to develop a hybrid system based on nicotinamide (NIC) and nanoparticles (NPs) encapsulating FK506, such as FK506-NPs-NIC, for facilitating percutaneous delivery, which exploited v...

Lowering Intraocular pressure (IOP) is a main therapeutic objective in glaucoma patients because IOP an important risk factor for progression. The of this work was to formulate and evaluate, vitro vivo, stable effective Solid Oil (S/O) topical formulation the antiglaucoma drug, timolol maleate (TM). S/O dispersions were prepared by emulsification aqueous TM solutions cyclohexane using different...

AIM The feasibility of transdermal delivery of naloxone, an opioid antagonist, by anodal iontophoresis patches using Ag/AgCl electrodes was investigated. METHODS To examine the effect of current strength, species variation and drug concentration on skin permeability of naloxone, in vitro skin permeation studies were performed using rat dorsal skin and porcine ear skin as the membrane. To dete...

Terconazole (Tr) is the first marketed, most active triazole for vaginal candidiasis. Owing to poor skin permeation and challenging physicochemical properties, Tr was not employed for the treatment of cutaneous candidiasis. This is the first study to investigate the relevance of novel lecithin-integrated liquid crystalline nano-organogels (LCGs) to improve physicochemical characteristics of Tr ...

Null mutations in the transient receptor potential (trp) gene eliminate the major, Ca2+-selective component of the light-sensitive conductance in Drosophila photoreceptors. Although it is the prototypical member of the TRP ion channel superfamily, conclusive evidence that TRP is a pore-forming channel subunit in vivo is lacking. We show here that mutating a specific acidic residue (Asp621) in t...

The process of passive drug absorption from the gastrointestinal tract is still poorly understood and modelled. Additionally, rapidly evolving field pharmaceutics demands efficient, affordable reliable in vitro tools for predicting vivo performance. In this work, we combined established methods quantifying diffusivity (localized UV-spectroscopy) permeability (Permeapad® plate) order to gain a b...

Background: Psoriasis is an autoimmune-mediated disease characterized marked by thickened plaques and erythematous skin, which can be treated topical delivery of apremilast. The objective this study was to prepare hydrogel-based nanoemulsions apremilast for psoriasis therapy with a view improving its solubility permeability. Methods: Nanoemulsion components were chosen based on their solubility...

Characterization and Ex Vivo Evaluation S. Tuncay Tanriverdi, O. Ozer Ege University Purpose The aim of this study to prepare Terbinafine hydrochloride (TBF-HCl) loaded liposome included film formulations for ungual therapy of onychomycosis. Ex-vivo nail permeation studies was performed with these formulations to investigate accumulation of TBF-HCl on nail plate. Methods The thin film hydration...

The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DF...