as the middle-aged in the society as well as stress-induced cognitive disorders and dementia are increasing, sport is identified as a suitable solution to prevent disorders in central nervous system. the aim of the present study was to compare the effects of 8 weeks of strength and endurance training on bdnf. for this purpose, 150 male wistar rats participated in endurance training (running wit...

  Purpose: This study investigated the effect of endurance activity on brain-derived neurotrophic   factor(BDNF), insulin-like growth factor 1(IGF-1) and its binding protein 3(IGFBP-3) in elderly   healthy individuals.   Materials and Methods: Eleven healthy old males (mean age of 68 ± 2.31 years old, height   of 177 ± 3.1 cm and weight of 79 ± 1.5 kg) were studied. Seventy two hours after maxi...

PURPOSE Voluntary loaded wheel running involves the use of a load during a voluntary running activity. A muscle-strength or power-type activity performed at a relatively high intensity and a short duration may cause fewer apparent metabolic adaptations but may still elicit muscle fiber hypertrophy. This study aimed to determine the effects of acute voluntary wheel running with an additional loa...

conclusions therapeutic dose of vitamin d can improve vitamin d status and glycemic indicators. but it seems that an 8-week intervention period was not sufficient to reveal the possible effects of vitamin d on serum adiponectin levels. results after 8-week intervention, serum 25-hydroxyvitamin d significantly increased and reached the normal levels in patients receiving vitamin d (p < 0.001) an...

Exercise can have a positive effect on the brain by activating brain-derived neurotrophic factor (BDNF)-related processes. In healthy humans there appears to be a linear relationship between exercise intensity and the positive short-term effect of acute exercise on BDNF levels (i.e., the highest BDNF levels are reported after high-intensity exercise protocols). Here we performed two experiments...

abstract          background and objective: vitamins c and e are  the two main antioxidants involved in prevention of type 2 diabetes, by reducing oxidative stress. the aim of this study was to evaluate the effects of vitamins c and e supplementation independently, on serum levels of insulin, high sensitivity c-reactive protein (hs-crp) and resistin in people with type 2 diabetes.         metho...

background exposure to morphine decreases neurogenesis in the hippocampus. recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. objectives this study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be re...

BACKGROUND Stroke rehabilitation with different exercise paradigms has been investigated, but which one is more effective in facilitating motor recovery and up-regulating brain neurotrophic factor (BDNF) after brain ischemia would be interesting to clinicians and patients. Voluntary exercise, forced exercise, and involuntary muscle movement caused by functional electrical stimulation (FES) have...

Introduction: The production of Reaction Oxygen Species (ROS), lowers cellular antioxidant levels, and enhances oxidative stress in many tissues, especially the liver. Efficient liver function is extremely important to the overall health. The key to helping prevent long-term damage is to decrease oxidative stress. The purpose of this study was to assess the effects of treadmill training with vi...