OBJECTIVES The Massachusetts Veterans Epidemiology Research and Information Center in collaboration with the Stanford Center for Innovative Study Design set out to test the feasibility of a new method of evidence generation. The first pilot of a point-of-care clinical trial (POCCT), adding randomization and other study processes to an electronic medical record (EMR) system, was launched to comp...

Single-molecule manipulation methods have opened a new vista on the study of molecular motors. Here we describe the use of magnetic traps for the investigation of the mechanism of DNA based motors, in particular helicases and translocases.

Clustering is an important technique for understanding of large multi-dimensional datasets. Most of clustering research to date has been focused on developing automatic clustering algorithms and cluster validation methods. The automatic algorithms are known to work well in dealing with clusters of regular shapes, e.g. compact spherical shapes, but may incur higher error rates when dealing with ...

In the past few years, the field of cancer immunotherapy has made great progress and is finally starting to change the way cancer is treated. We are now learning that multiple negative checkpoint regulators (NCR) restrict the ability of T-cell responses to effectively attack tumors. Releasing these brakes through antibody blockade, first with anti-CTLA4 and now followed by anti-PD1 and anti-PDL...

This paper reviews the search and analysis software packages QUEST3D and VISTA, also the database-building program PreQuest. The relationship between the CSD and the Protein Data Bank is discussed and development plans are outlined.

Clustering is an important technique for understanding of large multi-dimensional datasets. Most of clustering research to date has been focused on developing automatic clustering algorithms and cluster validation methods. The automatic algorithms are known to work well in dealing with clusters of regular shapes, e.g. compact spherical shapes, but may incur higher error rates when dealing with ...

In the past few years, the field of cancer immunotherapy has made great progress and is finally starting to change theway cancer is treated.We are now learning thatmultiple negative checkpoint regulators (NCR) restrict the ability of T-cell responses to effectively attack tumors. Releasing these brakes through antibody blockade, first with anti-CTLA4 and now followed by anti-PD1 and anti-PDL1, ...

Clustering is an important technique for understanding and analysis of large multi-dimensional datasets in many scientific applications. Most of clustering research to date has been focused on developing automatic clustering algorithms or cluster validation methods. The automatic algorithms are known to work well in dealing with clusters of regular shapes, e.g. compact spherical shapes, but may...

This paper reports on empirical evaluation study of users’ performance and satisfaction with prototype of Web Based speech photo annotation with speech interaction. Participants involved consist of Johor Bahru citizens from various background. They have completed two parts of annotation task; part A involving PhotoASys; photo annotation system with proposed speech interaction and part B involvi...

Ownership is an important aspect of software development in large software teams. We examine the relationship between a number of ownership measures and software faults/failures in three large software projects drawn from different process domains: Windows Vista, the Eclipse Java IDE, and the Firefox Web Browser. We find that in all cases, measures based on ownership levels, such as the number ...