Diagnosis of central nervous system (CNS) involvement in neoplastic diseases is a major problem. Recent progresses in chemotherapies and targeted therapies have improved survival in cancer patients. In this context of better-controlled systemic disease, brain metastases (BM) are emerging as a new challenge for the oncologist1. BM are one of the most common neurologic complications of cancer. Th...

BACKGROUND Since 1997, several countries within the Asian Pacific region have been affected by one or more massive outbreaks of Hand Foot and Mouth Disease (HFMD). Virus typing experiments revealed that these outbreaks were caused by strains of human enterovirus 71 (EV71) belonging to several different, recently emerged subgenogroups. In mainland China, a different situation was observed. The f...

the diwan school is one of the literary schools that emerged in contemporary arabic literature and had a tremendous role in directing arabic literature toward innovation, keeping it in touch with modern literary evolution worldwide in the twentieth century. however, the innovation that this school spread is by large of non-arabic roots and is chiefly based on such foreign literatures as english...

Cell-to-cell spread of HIV-1 between CD4(+) T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egre...

Implication for health policy/practice/research/medical education: Currently the prevalence of HCV is low in Iran. Viral spread is going to increase with the passage of time. Barbers and dentists practice procedures should also be standarized with HCV safety guidelines. It is highly needed to start massive awareness campaign in Iran against HCV to educate general population to contain the viral...

Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and its evasion both control infection outcomes, we used Mx1-cre mice to tag floxed viral genomes in IF...

Spinal anaesthesia is normally performed by puncture of the dura and arachnoid mater in the lumbar region, and local anaesthetic is introduced directly into the eerebrospinal fluid (CSF) surrounding the nerve roots and spinal cord. The solution will spread longitudinally through the CSF and the drug will be taken up by the neuronal tissue. Whether an effective concentration results in a particu...

West Nile virus (WNV) is an emerging pathogen that has decimated bird populations and caused severe outbreaks of viral encephalitis in humans. Currently, little is known about the within-host viral kinetics of WNV during infection. We developed mathematical models to describe viral replication, spread and host immune response in wild-type and immunocompromised mice. Our approach fits a target c...

Several studies have shown that enteric viruses can be transferred onto the surface of vegetables and fruits through spray irrigation, but, recently, reports have suggested viral contamination of vegetables sub-irrigated with reused wastewater. Hydroponic cultures, used to grow ready to eat fresh lettuce, have also been used to study the possibility of viral absorption through roots. This study...