Vinca alkaloids, vinblastine and vincristine sulfate, have a variety of effects on cells in vivo and in vitro (1-10) . In low sublethal doses, vinblastine and vincristine arrest cells in mitosis (1-3) and prevent the formation and organization of the spindle microtubules (2, 3) . Accumulation of large proteinaceous crystals in platelets (7), in tissue culture cells (8, 10), and in cells of the ...

We report a patient with acute lymphoblastic leukemia who developed severe atypical neuropathy (SAN), distinct from classical vincristine neuropathy, following the use of vincristine and granulocyte colony-stimulating factor (G-CSF). SAN was characterized by acute onset of severe pain, exquisite tenderness on even light touch and profound motor weakness involving predominantly the lower limbs. ...

Dear Editor, An 8-year-old boy, a known case of T-cell acute lymphoblastic leukemia (ALL), was admitted for an episode of fever and neutropenia. In preliminary investigations and based on chest computed tomography results, he was diagnosed as having pulmonary fungal infection, which was treated with conventional amphotericin B. Two weeks later, chest computed tomography showed no improvement of...

Eight non-splenectomized patients with corticosteroid-refractory idiopathic thrombocytopenic purpura (ITP) were treated with low-dose vincristine (1 mg/week up to a total dose of 4 mg). Complete remission was achieved in 2 cases and partial remission in 3. Bleeding stopped in one patient who failed to remit. No statistical relationship was found between the response to vincristine and the durat...

Vinca alkaloids, vinblastine and vincristine sulfate, have a variety of effects on cells in vivo and in vitro (1-10) . In low sublethal doses, vinblastine and vincristine arrest cells in mitosis (1-3) and prevent the formation and organization of the spindle microtubules (2, 3) . Accumulation of large proteinaceous crystals in platelets (7), in tissue culture cells (8, 10), and in cells of the ...

Vincristine concentration in serum from 1 min to 72 hr was measured by radioimmunoassay in 14 patients with cancers following i.v. bolus injection of Vincristine sulfate at 0.45 to 1.30 mg/sq m. The pharmacokinetic data were analyzed by a nonlinear least-square regression program NONLIN. A threecompartmental open model fitted the raw data better than a two-compartmental model. The mean half-liv...

Vincristine concentration in serum from 1 min to 72 hr was measured by radioimmunoassay in 14 patients with cancers following i.v. bolus injection of vincristine sulfate at 0.45 to 1.30 mg/sq m. The pharmacokinetic data were analyzed by a nonlinear least-square regression program NONLIN. A three-compartmental open model fitted the raw data better than a two-compartmental model. The mean half-li...