Antibody-drug conjugates (ADCs) have achieved great success in cancer therapy in recent years. Some peptidyl microtubule inhibitors consisting of natural and unnatural amino acids, such as monomethyl auristatin E (MMAE) and F (MMAF), are extremely cytotoxic and have been used as a payload in ADCs. However, their precise molecular interaction with tubulin and microtubules remains unclear. We det...

Application of anthracyclines and Vinca alkaloids on the same day represents a hallmark of polychemotherapy protocols for hematopoietic malignancies. Here we show, for the first time, that both drugs might act most efficiently if they are applied on different days. Proof-of-concept studies in 18 cell lines revealed that anthracyclines inhibited cell death by Vinca alkaloids in 83% of cell lines...

A recent survey of the effects of various physical and chemical parameters on yolk protein incorporation by isolated Xenopus oocytes indicates that the Vinca alkaloid vinblastine sulfate (VLB) is among the more effective inhibitors of this process (27) . The Vinca alkaloids have received considerable attention because of their ability to disrupt the integrity of microtubules (1, 2, 21) ; theref...

toxicity usually involves marrow suppression, with neurop athy a relatively infrequent occurrence (16). VDS, a new Vinca alkaloid undergoing clinical trials, may cause both a neuropathy and marrow suppression (13). The factors un denying these clinical differences have not been clarified. In light of the differing clinical effects of these 3 drugs on the peripheral nervous system, we have exami...

PREMISE OF THE STUDY Polymorphic microsatellite markers were developed in Vinca minor (Apocynaceae) to evaluate the level of clonality, population structure, and genetic diversity of the species within its native and introduced range. METHODS AND RESULTS A total of 1371 microsatellites were found in 43,565 reads from 454 pyrosequencing of genomic V. minor DNA. Additional microsatellite loci w...

(Fructan production in Vernonia herbacea (Vell.) Rusby is related to adequate nitrogen supply and period of cultivation). Previous studies showed that plants of Vernonia herbacea grown for one year under a limited nitrogen supply presented reduced growth and higher fructan content than plants treated with sufficient nitrogen supply. However, the total fructan production was similar in both plan...