Noninferiority trials are clinical studies designed to demonstrate that an investigational drug is at least as effective as an established treatment within a predetermined margin. They are conducted, in part, because of ethical concerns of administering a placebo to veterinary patients when an established effective treatment exists. The use of noninferiority trial designs has become more common...

The different factors (environmental, microbial contamination, handling procedures with game, post mortal changes of game meat) influenced on safety and quality of farmed and hunted wild game meat are described. The emphasis is given on residues of contaminants: risk chemical elements (Cd, Pb, Hg), mycotoxins (aflatoxin, ochratoxin, trichothecene), veterinary drug residues (sulfanilamid, amprol...

The present study was carried out to demonstrate novel use of pharmacokinetic approaches to characterize drug behaviors/movements in the vegetables with implications to food safety. The absorption, distribution, metabolism and most importantly, the elimination of tetracycline (TC) and sulfamethoxazole (SMX) in edible plants Brassica rapa chinensis and Ipomoea aquatica grown hydroponically were ...

background: antibiotics are an important class of drugs which are commonly used in veterinary for therapeutic, prophylactic and growth promotion purposes. antibiotic consumption may leave some residues in livestock food products leading to human health problems as well as failure in fermentation processing. the objective of this study was to investigate the antibiotic consumption pattern in ani...

Pig-house dust originates from feed, bedding, feces, and the animals themselves. If the animals receive drugs such as antibiotics, residues of these substances may occur in manure, in the air, or on surfaces of the respective animal house. In a retrospective study, we investigated dust samples collected during two decades from the same piggery for the occurrence of various antibiotics. In 90% o...

Residues of veterinary drugs, pesticides, and environmental contaminants in domestic and imported foods of animal origin were monitored by the National Residue Program and inspection service in Korea in the past decade. In all, 134 substances were analyzed in the monitoring plan; 35 substances were examined in the surveillance and enforcement testing program, and 27 substances were investigated...

This study reports an analytical method for the determination of nitroimidazole and quinolones in honey using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A modified QuEChERS methodology was used to extract the analytes and determine veterinary drugs in honey by LC-MS/MS. The linear regression was excellent at the concentration levels of 1-100 ng/mL in the solution standard curve ...

*Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Center for Veterinary Drug Residues, Canadian Food Inspection Agency, Saskatoon Laboratory, Saskatoon, SK, Canada; Departm...

Frequent and unregulated use of antimicrobials (AM) in livestock requires public health attention as a likely selection pressure for resistant bacteria. Studies among small-holders, who own a large percentage of the world's livestock, are vital for understanding how practices involving AM use might influence resistance. We present a cultural-ecological mixed-methods analysis to explore sectors ...

Methicillin-resistant Staphylococcus aureus (MRSA) has become a pathogen of animals. To compare types of infections, clinical outcomes, and risk factors associated with MRSA in dogs with those associated with methicillin-susceptible Staphylococcus aureus (MSSA) infections, we conducted a case-control study at 3 veterinary referral hospitals in the United States and Canada during 2001-2007. Risk...