We report our initial experience in two patients using real-time three-dimensional echocardiography to assess perimembranous ventricular septal defect and device morphology and their relation with contiguous cardiac structure. Defect size and rims as well as device position and profile were displayed from the three-dimensional "en face" views. We think that real-time three-dimensional echocardi...

Ventricular septal defect, alone or in combination with other cardiac malformations, is the commonest form of congenital heart disease in man. Morphogenically, the ventricular septum is composed of three parts: (a) the conal septum, (b) the septum of the endocardial cushions, and (c) the muscular septum proper. Consequently, most cono-truncal abnormalities (transposition of the great arteries, ...

Postmyocardial infarction ventricular septal defect is an increasingly rare mechanical complication of acute myocardial infarction. We present a case of acute myocardial infarction from right coronary artery occlusion that developed hypotension and systolic murmur 12 hours after successful percutaneous coronary intervention. Although preoperative imaging suggested a large ventricular septal def...

We applied successfully, a new surgical technique, in two children with transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction, that utilized aortic translocation with the aortic valve and the coronary arteries to the left ventricle, after correction of left outflow tract obstruction and correction of the ventricular septal defect, asso...

It has been demonstrated that intracardiac phonocardiography provides precise localization of the source of cardiovascular sounds. Can this technic be of practical help in the diagnosis of small or complicated ventricular septal defects? Is a ventricular septal1 defect ever silent? What mechanisiims are responsible for the diastolic mlurmlurs in ventricular septal defect? In an attempt to answe...

It has been demonstrated that intracardiac phonocardiography provides precise localization of the source of cardiovascular sounds. Can this technic be of practical help in the diagnosis of small or complicated ventricular septal defects? Is a ventricular septal1 defect ever silent? What mechanisiims are responsible for the diastolic mlurmlurs in ventricular septal defect? In an attempt to answe...

[1] Morell VO, Wearden PD. Aortic translocation for the management of transposition of the great arteries with a ventricular septal defect, pulmonary stenosis, and hypoplasia of the right ventricle. Eur J Cardiothorac Surg 2007;31:552—4. [2] Sayin OA, Ugurlucan M, Saltik L, Sungur Z, Tireli E. Modified Nikaidoh procedure for transposition of great arteries, ventricular septal defect and left ve...

Background—Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype. We assess here the role of genetic modifiers and their interactions. Methods and Results—Heterozygous Nkx2-5 knockout mice in the inbred strain background C57Bl/6 frequently have atrial a...

A case report of a 28-year-old patient, who presented with symptoms and signs of congestive heart failure and had clinical signs of ventricular septal defect as well. On further work-up echocardiogram showed non-compaction of the left ventricle with severe left ventricular systolic dysfunction and a ventricular septal defect. He was treated with standard treatment of heart failure and is doing ...

Twenty nine patients (aged from three months to 37 years) with confirmed or suspected ventricular septal defects were studied separately by three examiners who used colour flow mapping and imaging, or continuous wave Doppler and imaging, or a combined reference examination. Colour flow mapping identified 19 of the 25 patients with a ventricular septal defect, continuous wave Doppler echocardiog...