OBJECTIVE: To evaluate the respiratory systems of male and female rats maintained in individually ventilated cages (IVCs) from birth until adulthood. METHODS: Female Wistar rats were housed in individually ventilated cages or conventional cages (CCs) and mated with male Wistar rats. After birth and weaning, the male offspring were separated from the females and kept in cages of the same type ...

INTRODUCTION Air-space enlargement may result from mechanical ventilation and/or lung infection. The aim of this study was to assess how mechanical ventilation and lung infection influence the genesis of bronchiolar and alveolar distention. METHODS Four groups of piglets were studied: non-ventilated-non-inoculated (controls, n = 5), non-ventilated-inoculated (n = 6), ventilated-non-inoculated...

oral malignant melanoma (omm) accounts for 5% of all oral malignancies. it is a rare aggressive neoplasm usually found on the hard palate and gingiva. the etiology is unknown, but tobacco and chronic irritation are suggested as probable causative factors. over 30% of the cases have been reported to arise from pre-existing pigmented lesions. a biopsy is required to establish the diagnosis and th...

background: endotracheal or tracheostomy tube in mechanically ventilated patients disturb verbal communication with others. therefore, patients are frustrated of requesting for their needs or problems related to artificial breathing. therefore investigating self-experiences of these patients can be applied in providing them with a better care by clinical personnel. methods: this is a qualitativ...

The aim of this study was to develop a technique for the collection of exhaled breath condensate (EBC) from ventilated children and assess its safety and feasibility. Collection of EBC is used to investigate markers of oxidative stress in the lower airway. No studies have assessed its safety in ventilated children. An in vitro model was developed by connecting a ventilator to an artificial lung...

OBJECTIVE Four-hour comparison of the bronchodilator response of albuterol administered via metered-dose inhaler (MDI) with spacer versus small-volume nebulizer (SVN) to mechanically ventilated patients with chronic obstructive pulmonary disease (COPD). DESIGN Prospective randomized clinical trial. SETTING Medical intensive care unit in a university hospital. PATIENTS Thirteen mechanicall...

Short-term mechanical ventilation with high tidal volume (HVT) causes mild to moderate lung injury and impairs active Na+ transport and lung liquid clearance in rats. Dopamine (DA) enhances active Na+ transport in normal rat lungs by increasing Na+-K+-ATPase activity in the alveolar epithelium. We examined whether DA would increase alveolar fluid reabsorption in rats ventilated with HVT for 40 ...

background: the purpose of our study was to evaluate an inexpensive and available method to reduce mucous impactions in mechanically ventilated patients. methods: this randomized clinical trial was conducted on 40 mechanically ventilated patients aged 15-90 years. the patients were randomly allocated into two arms; 20 cases and 20 controls. the cases received n-acetylcysteine via their nebulize...