Vascular endothelial growth factors (VEGFs) are key mediator of retinal and choroidal neovascularization as well vascular leakage leading to macular edema. As such, VEGF plays an important role in mediating visually significant complications associated with common disorders such diabetic retinopathy, vein occlusion, age-related degeneration. Various drugs that inhibit (anti-VEGF therapies) have...

Purpose: To investigate the effects of vascular endothelial growth factor (VEGF) on yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding motif (TAZ), Hippo pathway-related transcription factor, and role YAP/TAZ induced by trabecular meshwork stimulation.Methods: Human cells were cultured treated various VEGF concentrations to verify cell cytotoxicity using CCK-8 solution....

background: one of the promising methods in fertility preservation among women with cancer is cryopreservation of ovarian cortex but there are many drawbacks such as apoptosis and considerable reduction of follicular density in the transplanted ovary. one solution to reduce ischemic damage is enhancing angiogenesis after transplantation of ovarian cortex tissue. objective: the aim of this study...

Background Establishment of viable pregnancy requires embryo implantation and placentation. Ectopic pregnancy (EP) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube. On the other hand, an important aspect of successful implantation is angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor...

Vascular endothelial growth factor (VEGF), a clinically important biomarker, often plays key role in angiogenesis, would healing, tumor growth, lung development, and retinal diseases. Hence, detecting quantifying VEGF is deemed medically clinical diagnosis for many In this report, simple yet highly cost-effective platform was proposed protein detection using commercially available interdigitate...

Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/...

Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis. This includes developmental angiogenesis as the loss of a single allele is embryonic lethal due to lack of development of endothelial cells. During early development, endothelial cells depend on VEGF for survival and if it is withdrawn, massive apoptosis results. This is not true in adult organisms; withdrawal of...

previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...