It can, therefore, be assumed that NO− # could act as an indirect vasodilator. In an article recently published in Clinical Science, Demoncheaux et al. [1] have addressed this issue by performing sophisticated experiments in vitro with rings of pulmonary arteries, and reported that the concentration of NO− # derived from dissolved NO (NO solv ) in aqueous solutions of NaNO # at pH 7.4 cannot ac...

The vasodilator effects of pituitary adenylate cyclase activating polypeptide (PACAP-27) are subject to tachyphylaxis in rats treated with the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). This study examined whether this tachyphylaxis is due to the loss of vasodilator potency of cAMP generated by activation of the G(s) protein-coupled PACAP receptors. Five succes...

Conduction of changes in diameter plays an important role in the coordination of peripheral vascular resistance, and thereby, in the control of arterial blood pressure. It is thought that conduction of vasomotor signals relies on the electrotonic spread of changes in membrane potential from a site of stimulation through gap junctions connecting the cells of the vessel wall. To explore this idea...

CHEST / 105 / 3 / MARCH, 1994 / Supplement 87S Inhaling Nitric Oxide: A Selective Pulmonary Vasodilator and Bronchodilator* Warren M. Zapol, M.D., F.C.C.P.; Konrad J. Falke, M.D.; William E. Hurford, M.D., F.C.C.P.; and Jesse D. Roberts, Jr., M.D. I n a number of animal models and clinical pulmonary diseases of human subjects, inhaled nitric oxide (NO) is now firmly established as a selective p...

Background Myocardial vasodilator reserve is an important surrogate marker of normal and abnormal cardiac physiology. Pharmacological vasodilator agents such as adenosine increase myocardial blood volume, which is expected to prolong the observed T1-relaxation. We explored the novel application of stress T1-mapping by assessing the response of myocardial T1 to the administration of adenosine in...

Cutaneous arterioles are controlled by vasoconstrictor and active vasodilator sympathetic nerves. To find out whether the active vasodilator system is under baroreceptor control, laser-Doppler velocimetry and the local iontophoresis of bretylium were combined to allow selective study of the active vasodilator system. Each of six subjects had two forearm sites (0.64 cm2) treated with bretylium t...

Vasodilator Response to Local Hyperinsulinemia To the Editor: Cardillo et al recently reported that systemic but not local hyperinsulinemia causes nitric oxide (NO)-dependent vasodilatation.1 They suggest that mechanisms stimulated only by systemic but not local hyperinsulinemia contribute to insulinmediated vasodilatation. We believe that this conclusion is mistaken. The changes in forearm blo...