(PVR), macular degeneration, and retinitis pigmentosa (RP), can lead to blindness without timely treatment. Vascular endothelial growth factor (VEGF) has been identified as a key promoting vascular leakage angiogenesis, making neutralization of VEGF the first-line therapy for ischemic retinopathies such DR retinal occlusions. However, not all patients with these respond anti-VEGF therapy, neces...

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by progressive and irreversible obstruction of the airways of the lungs. Different studies have emphasized on the role of Vascular Endothelial Growth Factor (VEGF) in COPD patients. The aim of this study was to investigate the relationship of this factor with disease severity and th...

PURPOSE To determine whether vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which have been implicated in the development of retinal and choroidal neovascularization, are present in the retinas and optic nerves of patients with diabetes before proliferative retinopathy appears. METHODS Light microscopic immunocytochemistry using antibodies to VEGF, bFGF, ...

Kaposi sarcoma (KS) is the most common tumor associated with HIV-1 infection and develops in nearly 30% of cases. The principal features of this tumor are abnormal vascularization and the proliferation of endothelial cells and spindle (tumor) cells. KS-derived spindle cells induce vascular lesions and display enhanced vascular permeability when inoculated subcutaneously in the nude mouse. This ...

development of phytotherapies aimed at angiogenesis inhibition, in combination with classical anti-cancer therapies, is among the most intensively studied approaches for treatment of cancer. epidemiological and animal studies have indicated that consumption of allium species like shallot is associated with a reduced risk of cancer development. as a continuation of our efforts to study and chara...

Endothelial injury is an important prognostic factor in acute respiratory distress syndrome (ARDS). Decreased production of vascular endothelial growth factor (VEGF) in ARDS may favour vascular lesions, since VEGF promotes endothelial survival by inhibiting apoptosis. This study sought to document low VEGF levels in lung tissue from ARDS patients, to determine whether the cause was injury to al...