objective(s) ziziphora clinopodioides lam. is a plant widely used in iranian traditional medicine for gastrointestinal disorders. several reports have demonstrated antibacterial (helicobacteria pylori), antioxidant and anti­inflammatory properties of z. clinopodioides. the aim of this study was to investigate the effects of aqueous- ethanol extract of z. clinopodioides on rat’s gastric acid out...

Post-vagotomy Gastroparesis occurs in 15-50% of patients following esophagectomy with gastric interposition, and results in aspiration pneumonia, persistent nausea, intolerance of oral intake, weight loss, and poor quality of life (QoL). Subsequently, this can contribute to significant morbidity and mortality in these patients. Currently, the efficacy of pyloric drainage procedures to prevent p...

Biopsy specimens have been taken from five standard sites in the stomach and from the duodenal bulb in order to investigate the association of gastritis and duodenitis with duodenal ulcer. Twenty patients with chronic duodenal ulcer were investigated in this manner and in addition had gastric secretion tests and a radio-immune assay of serum gastrin under differing conditions. The patients were...

Acetylcholine, the parasympathetic neurotransmitter, shortens the action potential duration of cat atrial muscle cells, but not ventricular muscle cells. In mammalian species, atrial tissue receives a richer cholinergic nerve supply than ventricular tissue. To determine whether chronic withdrawal of cholinergic tone might influence the subsequent response of these tissues to cholinergic stimula...

The influence of vagotomy on resting vagal tone arterial Po2, the heart rate and blood pressure responses to different grades of hypoxia was studied in three species of anesthetized animals. Vagotomy without hypoxia produced a sustained increase in heart rate of dogs but not in rabbits or sheep. In the dogs, where this was studied more fully, heart rate showed sustained increase over several ho...

Unilateral vagotomy causes atrophy of the denervated fundic mucosa in rat stomachs. We examined whether or not unilateral vagotomy delays healing of gastric ulcers induced on the denervated mucosa. Kissing ulcers were induced in the fundus of rat stomachs by intraluminal application of an acetic acid solution. Anterior unilateral vagotomy was performed subdiaphragmatically at the time of ulcera...

Anticancer agents, such as cisplatin, induce vomiting, nausea, and anorexia. Cisplatin primarily acts on vagal afferents to produce emesis, but little is known about how this drug generates nausea and anorexia. Electrophysiology indicates that cisplatin activates vagal afferents of the common hepatic branch (CHB). Rats lack an emetic response but do ingest kaolin clay (a pica response) when mad...

Although the importance of the vagal nerve in the pathogenesis of bronchial asthma has been reported, its precise contribution is still not fully understood. To shed more light on this area, we evaluated the possible contribution of vagal reflex in histamine-induced bronchoconstriction (HIB), and decided the site of action of histamine on the vagal nerve. For this purpose, we studied the effect...

two cases of recurrent ulcer within a few months of H.S.V. in a small series, and 22% of Kronborg and Madsen's (1975) 50 patients developed recurrent ulceration within four years of H.S.V. The early postoperative insulin test, however, showed that 58% of Kronborg and Madsen's patients and 28% of those of Wastell et al., had incomplete vagotomy. Since there is a good correlation between insulin ...

IN 1943 Dragstedt & Owens changed the established surgical treatment for chronic duodenal ulceration by re-introducing the operation of vagotomy. It was rapidly recognized that, together with vagotomy, a gastric drainage procedure of some type was essential (Dragstedt & Schafer, 1945). In its early years, vagotomy and drainage rapidly gained in popularity on the basis of simplicity and the low ...