We studied the effects of intravenous ouabain administration (15 micrograms/kg) and vagal stimulation on instrumented conscious dogs. In these dogs, a special electrode was implanted on the epicardial surface over the sinus node and plaque electrodes were placed on the superior vena cava and left atrial appendage. Unipolar sinus electrograms were recorded through the terminals of the sinus elec...

Visceral pain is an important therapeutic problem. A number of studies have established that abdominal vagal afferents modulate somatic pain behavior. Although it is not clear if vagal afferents transmit nociceptive information, a change in their activity can increase or decrease nociceptive transmission in visceral pain. Aims of the present study were to determine whether the subdiaphragmatic ...

We have recently shown that the intrinsic rate response to an increase in right atrial pressure is augmented when cardiac muscarinic receptors are activated. This present study examines the cardiac pacemaker response to vagal stimulation at different values of right atrial pressure in isolated rat right atrium and in the rabbit heart in situ. In the rat atrium, when pressure was raised in steps...

1. the oesophageal plexus is in the structure and arrangement of its larger branches constant. ·2 . two trunks arise from the oesophageal plexus, the . anterior vagal trunk and the posterior vagal trunk; each trunk contains fibers of both left and right vagi nerves. 3. these vagal trunks in the majority of instances pass through the oesophageal opening of the diaphragm each in the form of the o...

The purpose of this study was to explore learning and memory in the Hering-Breuer (HB) reflex simulated by a 60-second-long electrical stimulation of vagus nerve. The responses of phrenic nerve discharge to electrical stimulation (10-100 Hz, 20-60 muA, pulse duration 0.3 ms, for 60 s) of the vagus nerve were observed in rabbits. The results showed that 60-second-long stimulation of vagus nerve ...

Implantable medical devices are finding increasing use in the treatment of diseases traditionally targeted with drugs. It is well established that the cholinergic anti-inflammatory pathway serves as a physiological regulator of inflammatory responses, but stimulation of this pathway therapeutically by electrical stimulation of the vagus nerve can also diminish excessive or dysregulated states o...

Disclaimer: This article has been published immediately upon acceptance (by the Editors of the journal) as a provisional PDF from the revised version submitted by the authors(s). The final PDF version of this article will be available from the journal URL shortly after approval of the proofs by authors(s) and publisher. Abstract: Objectives: Sympathetic overactivity and vagal withdrawal are car...