In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

Respir Dis 1992; 146:485–491 7 Griese M, Rampf U, Hofmann D, et al. Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr Pulmonol 2000; 30:393–401 8 Oshima Y, Takahashi S, Nagayama H, et al. Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT). Bone Marrow...

Bone marrow fibrosis is a hallmark of primary and post ET/PV myelofibrosis. To investigated the impact of replacement of the hematopoietic system in myelofibrosis patients by allogeneic stem cell transplantation on bone marrow fibrosis, we studied bone marrow fibrosis on bone marrow samples from 24 patients with myelofibrosis before and after dose-reduced conditioning followed by allogeneic ste...

plantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor. Blood 1995; 85:1666-72. 5. Elmaagacli AH, Beelen DW, Becks HW, et al. Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation. Bone Marrow Transplant 1996; 18:397-403. 6. Schwartzberg L, Bi...

Autoimmune diseases are an important field for the development of hematopoietic stem cell transplantation (HSCT). The Brazilian Society Cellular Therapy and Bone Marrow Transplantation (Sociedade Brasileira de Terapia Celular e Transplante Medula Óssea, SBTMO) organized consensus meetings Diseases Group, to review available literature on HSCT autoimmune diseases, aiming gather data that support...

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haematologica/journal of hematology vol. 88(07):july 2003 835 two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplant 2001;28:463-71. 6. Maury S, Mary JY, Rabian C, Schwarzinger M, Toubert A, Scieux C, et al. Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients. Br J Hematol 2001;115:630-41. 7. D...

Long-term functional capacities of marrow cell lines were defined by competitive repopulation, a technique capable of detecting a small decline in repopulating abilities. There was little or no difference between cells from old and young donors, but a single serial transplantation caused a large decline in repopulating ability. Varying the numbers of marrow cells transplanted into the initial c...

during the last two decades conventional therapy has improved the prognosis of thalassemia. however, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. bone marrow transplantation (bmt) can prevent or delay progression of the aforementioned complications. the importance of clinical research...

isolated extramedullary relapse of chronic myelogenous leukemia (cml) after allogeneic stem cell transplant is rare. there is a case report of a child who developed a granulocytic sarcoma of the maxillary and sphenoid sinuses and lumbosacral spinal cord mass 18 months after allogeneic bone marrow transplant for cml. he was presented with per orbital edema and neurological deficit of lower extre...