The birth of a child after uterus transplant from a living donor in Sweden in October, 2013 has spurred reproductive and transplant physicians in Europe and North America to investigate whether uterus transplants, from living or cadaveric donors, will be a safe and effective therapy for women with uterine insufficiency. While progress with uterus transplant depends on medical factors, there are...

In the current study, we investigated the expression and activity of ACE2 during pregnancy in normotensive and hypertensive rats, focusing on the relative contribution of the uterus and the placentas, the kidney serving as a reference. We used the Sabra rat model of salt-sensitive hypertension. We confirmed a systemic vasodilatory state during the third trimester of pregnancy, as evidenced by a...

background: punica granatum linn. (pg) is native to the mediterranean region. its flower exhibited antioxidant activity. the present study attempt to investigate the effect of these extract on uterine contraction and its possible mechanism(s). methods: thirty five female wistar rats (200-300 g) at estrous phases of cycle was examined in this study; pieces of virgin adult rat uterus (1.5 cm) wer...

background: receptor for hyaluronic acid mediated motility (rhamm) has intracellular and extracellular functions. in this study, we focus on the expression of rhamm in the rat uterus during estrous cycle and implantation period. methods: the female adult rats were divided into six groups following estrous cycle determination (n=36). the utreri of rats were collected according to estrous cycle p...

background: embryo transfer has received little clinical attention and has been the most inefficient step in in-vitro fertilization (ivf). recent reports have suggested that an awareness of the position and length of the uterus during embryo transfer might be helpful in improving pregnancy rate. objectives: the main objective of the present study was to determine the relation between the length...

Endometrial cancer Double uterus Histopathology Abstract We report a rare case of endometrial carcinoma arisen from both horns of an asymmetrical double uterus. Dr. Yoshiharu Tsukahara, Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390 (Japan) Introduction Although the incidence of a malformed uterus is not so rare, there have been few re...

Background and Objective: Uterus of rat with polycystic ovary (PCO) may show pathological features. We provided pathological evidence for the rat uterus with NO-induced PCO.    Materials and Methods: Wistar rats (weighing 200-250 g) were kept diestrous to receive L-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. Control group solely received saline (1 ml/kg, 9 days/once per ...

Uterus development during pre-implantation stage affects implantation process and embryo growth. Aberrant uterus development is associated with many human reproductive diseases. Among the factors regulating uterus development, vascular remodeling promoters are critical for uterus function and fertility. Vascular endothelial growth factor (VEGF), as one of the major members, has been found to be...

Complete bicornuate uterus is a type of Mullerian duct deformity, resulting from abnormal duct fusion. Similar to other Mullerian anomalies, bicornuate uterus is associated with specific complications during possible pregnancies. While various studies have reported successful deliveries in a bicornuate uterus, it might be accompanied with various complications, ranging from preterm labor to mor...