نتایج جستجو برای: uterine cancer
تعداد نتایج: 942172 فیلتر نتایج به سال:
BACKGROUND Laparoscopy-assisted vaginal hysterectomy is one of the definite methods for the treatment of symptomatic uterine fibroids with lesser intraoperative bleeding and shorter hospitalization compared with abdominal hysterectomy. However, laparoscopy-assisted vaginal hysterectomy cannot preserve uterus and can show postoperative complications by the change of pelvic structure. Thus, lapar...
This paper presents a single-institution experience regarding the clinicopathologic features and treatment strategies used in uterine clear cell cancer (UCC), a rare, aggressive histologic subtype of uterine cancer with poor prognosis and discusses parameters associated with progression-free survival (PFS) and overall survival (OS). A retrospective chart review was performed on all patients (n ...
We have reported that a novel tumor-associated antigen (Ag), 22-1-1, was expressed in cancer cells derived mainly from the uterus and ovary [K. Sonoda et al., Cancer (Phila.), 77: 1501-1509, 1996]. The 22-1-1 Ag existed not only in adenocarcinomas but also in squamous cell carcinomas in the uterine cervix. Here, a relationship between tumor progression and invasion and 22-1-1 Ag expression was ...
AIM Severe late complications, particularly radiation enterocolitis and leg edema, remain major problems in patients with uterine cancer, who have undergone hysterectomy and postoperative external beam radiotherapy (EBRT). We carried out this retrospective analysis to identify the incidence of risk factors for such complications. PATIENTS AND METHODS The records of 228 patients, who underwent...
Modern Methods of Early Detection of Endometrial Cancer on the Example of “Pipelle” Urogenital Probe
Today, at a time when cancer is developing rapidly, number of scientific studies are being conducted worldwide in the field early detection, prevention and treatment disease. A new methods recommended by experts to put into practice, which convenient, effective, rapid, uncomplicated painless detection tumor diseases especially uterine women.
OBJECTIVE To review the use of tissue morcellation in minimally invasive gynaecological surgery. OUTCOMES Morcellation may be used in gynaecological surgery to allow removal of large uterine specimens, providing women with a minimally invasive surgical option. Adverse oncologic outcomes of tissue morcellation should be mitigated through improved patient selection, preoperative investigations,...
aretaeus of cappadokia, lived in an era when cancer was already a disease, well known for its deadly outcome. inside his momentous treatise, composed of 8 books, he had outlined various types of cancer. he had understood cancer’s fatality and proposed some curative treatments. our manuscript composes the fragments related to cancer, in an effort to present aretaeus’ views on the matter. he had...
PURPOSE Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss a...
BACKGROUND Progesterone is a key hormonal regulator of the female reproductive system. It plays a major role to prepare the uterus for implantation and in the establishment and maintenance of pregnancy. Actions of progesterone on the uterine tissues (endometrium, myometrium and cervix) are mediated by the combined effects of two progesterone receptor (PR) isoforms, designated PR-A and PR-B. Bot...
PTEN is known to be frequently mutated in uterine cancer and also dephosphorylates FAK. Here, we examined the impact of PTEN alterations on the response to treatment with a FAK inhibitor (GSK2256098). In vitro and in vivo therapeutic experiments were carried out using PTEN-mutated and PTEN-wildtype models of uterine cancer alone and in combination with chemotherapy. Treatment with GSK2256098 re...
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