نتایج جستجو برای: urothelial carcinoma in situ
تعداد نتایج: 17047993 فیلتر نتایج به سال:
the focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. for this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (dcis), was evaluated by immunohistochemical method. all specimens were microscopically classified into histologic types...
Background: Urothelial carcinoma of the bladder is common cancer. Despite advances in treatments and introduction immune checkpoint inhibitors recent years, metastatic disease carries a poor prognosis
Human endogenous retroviruses (HERV) and related elements account for more than 8% of the human genome and significantly contribute to the human transcriptome by long terminal repeat (LTR) promoter activity. In this context, HERVs are thought to intervene in the expression of adjacent genes by providing regulatory sequences (cis-effect) or via noncoding RNA including natural antisense transcrip...
In this video Mello et al. (1), demonstrate the case of a Robot assisted segmental ureterectomy for a patient with a solitary kidney with high medical co-morbidities that had a single localized ureteral lesion consistent with a urothelial neoplasm. The surgical team carefully diagnosed and staged the ureteral tumor. A formal cystoscopy, bladder washing cytologies, retrograde pyelogram and urete...
BACKGROUND MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They are aberrantly expressed in many types of cancers. In this study, we determined the genome-wide miRNA profiles in bladder urothelial carcinoma by deep sequencing. METHODOLOGY/PRINCIPAL FINDINGS We detected 656 differentially expressed known human miRNAs and miRNA antisense sequences (miRNA*s)...
MicroRNA is known to be an important regulator of gene expression. The microRNAs that were found to be differentially expressed in normal urothelium and urothelial carcinomas in the literature were selected and meaningful microRNAs were validated using urothelial tumor cells lines; formalin-fixed and paraffin-embedded (FFPE) tissues; and urine samples for both the definitely benign and malignan...
OBJECTIVE Bladder urothelial carcinoma is a common tumor in humans and a multifactorial disease. The gene mex3a is associated with tumor formation and may promote cell proliferation and migration. Therefore, this study aimed to determine the relationship between mex3a and bladder urothelial carcinoma. METHODS The clinical and RNA sequencing expression data in patients with bladder urothelial ...
OBJECTIVE To evaluate the clinical significance of lymphovascular invasion (LVI) on recurrence and progression rates in patients with pT1 urothelial carcinoma of bladder after transurethral resection. METHODS This retrospective study was performed with 155 patients with newly diagnosed pT1 urothelial carcinoma of bladder who were treated with transurethral resection of bladder tumor at our in...
Carcinosarcoma is a rare biphasic neoplasia containing both malignant mesenchymal and epithelial elements. Bladder carcinosarcoma commonly presented as high-grade, advanced stage, and aggressive behavior with a poor prognosis. An 83-year-old male presented with painless gross hematuria to our hospital. Cystoscopy revealed massive nonpapillary bladder tumor on the right wall. The 91 g tumor coul...
PURPOSE We studied the safety and efficacy of multiple adjuvant apaziquone instillations in patients with high risk nonmuscle invasive bladder cancer. MATERIALS AND METHODS Patients with high risk nonmuscle invasive urothelial carcinoma of the bladder underwent transurethral resection of all bladder tumor(s), and received 6 weekly adjuvant intravesical apaziquone instillations of 4 mg in 40 m...
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